ArticleFrontiers in microbiology2026
High-fat diet induces an adaptive dysbiosis in the gut microbiota, associated with oxidative stress and the gut resistome profile in a rat model.
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Antibiotic resistance is one of the main public health issues worldwide; therefore, studying the factors contributing to this problem, including the reservoirs of antibiotic resistance genes, is highly relevant. Among these reservoirs, the gut microbiota stands out for its potential to disseminate antibiotic resistance genetic determinants. In this context, identifying the factors shaping the gut resistome is crucial. This study aimed to evaluate the effects of a high-fat diet (HFD) on intestinal and systemic oxidative stress in a rat model and to assess its impact on the gut microbiota, its DNA oxidative damage, and the resistome. Oxidative stress was evaluated by quantifying oxidative stress markers in the host (MDA, T-SOD, and T-GSH/GSSG) and in the gut microbiota (8-OHdG), while the impact on the gut microbiota was determined using a shotgun metagenomic sequencing approach. The effect of HFD on oxidative stress, the gut microbiota, and its resistome was evaluated after 4, 8, and 12 weeks of exposure, with and without supplementation with an antioxidant (N-acetylcysteine). Results showed that a high-fat diet generates a pro-oxidant stimulus in intestinal tissue, with increased lipid peroxidation and superoxide dismutase activity, without systemic effects. In the gut microbiota, HFD altered microbial diversity, without DNA oxidative damage. Analysis of the predominant genera revealed an increased abundance of
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