Evidence map›Paper›PMID 42903192›Full record

ArticleFrontiers in immunology2026

A

Inmaculada Vico-Barranco, Fanghui Zhang, Claude Grégoire, Luis M Fernández-Aguilar, Mikel M Arbulo-Echevarria, Isaac Narbona-Sánchez, Raquel Muñoz-Fernández, Bernard Malissen, Marie Malissen, Enrique Aguado

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Inmaculada Vico-Barranco *Department of Biomedicine, Biotechnology and Public Health, Universidad de Cádiz, Cádiz, Spain.
Fanghui Zhang *Centre d'Immunologie de Marseille-Luminy (CIML), Aix Marseille Université, INSERM, CNRS, Marseille, France.
Claude GrégoireCentre d'Immunologie de Marseille-Luminy (CIML), Aix Marseille Université, INSERM, CNRS, Marseille, France.
Luis M Fernández-AguilarDepartment of Biomedicine, Biotechnology and Public Health, Universidad de Cádiz, Cádiz, Spain.
Mikel M Arbulo-EchevarriaDepartment of Biomedicine, Biotechnology and Public Health, Universidad de Cádiz, Cádiz, Spain.
Isaac Narbona-SánchezDepartment of Biomedicine, Biotechnology and Public Health, Universidad de Cádiz, Cádiz, Spain.
Raquel Muñoz-FernándezDepartment of Biomedicine, Biotechnology and Public Health, Universidad de Cádiz, Cádiz, Spain.
Bernard MalissenCentre d'Immunophénomique (CIPHE), Aix Marseille Université, INSERM, CNRS, Marseille, France.
Marie Malissen *Centre d'Immunophénomique (CIPHE), Aix Marseille Université, INSERM, CNRS, Marseille, France.
Enrique Aguado *Department of Biomedicine, Biotechnology and Public Health, Universidad de Cádiz, Cádiz, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The tyrosine kinase ZAP-70 is essential for T-cell activation and development, but the mechanisms regulating its activity remain unclear. Previous studies showed that the Src-family kinase LCK binds phosphorylated tyrosine 319 of ZAP-70 via its SH2 domain. Additionally, a gain-of-function ZAP-70 mutation involving the YEEI motif enhances LCK recruitment and TCR-mediated signaling. To investigate the physiological consequences of enhanced ZAP-70-LCK interaction

Indexed as

Gain of Function MutationThymus GlandT-Lymphocytes, RegulatoryZAP-70 Protein-Tyrosine KinaseAnimalsCell DifferentiationLymphocyte ActivationLymphocyte Specific Protein Tyrosine Kinase p56(lck)MiceMice, Inbred C57BLMice, TransgenicSignal TransductionThymocytesLymphocyte Specific Protein Tyrosine Kinase p56(lck)Zap70 protein, mouseZAP-70 Protein-Tyrosine KinaseLCKTCR signalingthymic developmentTregZAP-70

Identifiers

PMID42903192
PMCPMC13680439

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.