Evidence map›Paper›PMID 42903149›Full record

ArticleFrontiers in cellular neuroscience2026

Daily regulation of glucocerebrosidase activity and impact of fixed-time rotarod training in a mouse model of

Chiara Bertasini, Shima Tavakolian Haghighi, Maria Giusy Bruno, Fabio Paio, Carlo Alberto Artusi, Matteo Brunelli, Federico Schena, Massimo Venturelli, Ugo Moretti, Maria Grazia Romanelli and 1 more

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In one paragraph

Article in Frontiers in cellular neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chiara BertasiniDepartment of Diagnostics and Public Health, Section of Pharmacology, University of Verona, Verona, Italy.
Shima Tavakolian HaghighiDepartment of Diagnostics and Public Health, Section of Pharmacology, University of Verona, Verona, Italy.
Maria Giusy BrunoDepartment of Neurosciences, Biomedicine and Movement Sciences, Section of Biology and Genetics, University of Verona, Verona, Italy.
Fabio PaioDepartment of Neurosciences, Biomedicine and Movement Sciences, Section of Clinical Neurology, University of Verona, Verona, Italy.
Carlo Alberto ArtusiDepartment of Neurosciences, Biomedicine and Movement Sciences, Section of Clinical Neurology, University of Verona, Verona, Italy.
Matteo BrunelliDepartment of Diagnostics and Public Health, Section of Pathology, University of Verona, Verona, Italy.
Federico SchenaDepartment of Neurosciences, Biomedicine and Movement Sciences, Section of Movement Sciences, University of Verona, Verona, Italy.
Massimo VenturelliDepartment of Neurosciences, Biomedicine and Movement Sciences, Section of Movement Sciences, University of Verona, Verona, Italy.
Ugo MorettiDepartment of Diagnostics and Public Health, Section of Pharmacology, University of Verona, Verona, Italy.
Maria Grazia RomanelliDepartment of Neurosciences, Biomedicine and Movement Sciences, Section of Biology and Genetics, University of Verona, Verona, Italy.
Giovanna PaoloneDepartment of Diagnostics and Public Health, Section of Pharmacology, University of Verona, Verona, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Mutations in the glucocerebrosidase ( Methods: C57BL/6J healthy controls and Results: Our results showed that rotarod performance was influenced by genotype-dependent vulnerabilities and by daily, fixed-time physical activity, with overall better performance during the dark-phase training. The fluorometric assay revealed that GCase activity shows a ZT-dependent daily pattern in healthy mice, whereas this pattern was disrupted in Discussion: Overall, both the time of day and daily fixed-time physical activity influenced GCase regulation. Our findings reveal a functional interplay between daily biological timing and lysosomal enzyme regulation, suggesting that optimizing drug dosing and timing of administration may improve the efficacy of GCase-targeted treatments.

Indexed as

dailyfixed-time rotarod traininghSNCAA53T Gba1+/+hSNCAA53T Gba1+/L444Pplasma GCase activitytime-of-day variation

Identifiers

PMID42903149
PMCPMC13680190

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.