ArticleFrontiers in oncology2026
Ecological drivers of the colon cancer microbiome: evidence for niche-based selection over stochastic colonization.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Colon cancer is a leading global malignancy influenced by genetic, environmental, and microbial factors. This study integrates ecological theories, including Hubbell's neutral theory, augmented by Ning et al.'s (2019, PNAS) stochasticity analysis framework, and classic niche theory, to assess the contributions of stochastic colonization and deterministic niche selection in shaping microbiome assembly and dynamics in colon cancer tissues. Specialist species were identified using Levins' niche breadth analysis. By reanalyzing the datasets from Nejman et al., including 22 normal adjacent tissue (NT) and 22 primary tumor (PT) samples, we find: (i) deterministic niche selection appears to dominate community assembly and diversity maintenance in both NT and PT microbiomes, as demonstrated by the normalized stochasticity ratio (NSR: 0.267 for NT, 0.287 for PT; both below 0.5; Wilcoxon PT>NT, p=0.027). Only 18.2% NT and 27.3% PT samples fit the neutral model, confirming stochastic drift plays a limited role and niche selection predominates in structuring tissue microbiomes. (ii) Through niche breadth analysis, we identified 106 specialist species, of which 14 are known CRC-associated taxa, including
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