ArticleFrontiers in immunology2026
A subunit vaccine protects A129 mice from death and joint swelling against lethal Chikungunya virus challenge.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Chikungunya virus (CHIKV) is primarily transmitted to humans through bites of infected Methods: We engineered mammalian cells to produce the ectodomains of the E1 and E2 glycoproteins and evaluated the protective efficacy of the resulting vaccine formulations Results: A two-dose vaccination regimen elicited high levels of antibodies and provided full protection against lethal challenge in A129 mice, preventing both death and joint swelling. Discussion: These findings demonstrate the potential of this vaccine candidate against CHIKV and warrant its further development.
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