ArticleFrontiers in neurology2026
Development of the LARyNGTH score to predict central neurogenic respiratory failure in lateral medullary infarction.
Article in Frontiers in neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Central neurogenic respiratory failure (CNRF) is a fatal complication associated with lateral medullary infarcts (LMI). Its detection may be critical for timely intervention and to reduce the risk of mortality. This study aimed to identify the clinical predictors of CNRF in patients with LMI. Methods: This study included patients with LMI who were admitted to a university hospital between 2010 and 2022. CNRF was defined as unexpected intubations due to hypercapnia, cardiopulmonary resuscitation owing to respiratory causes, or clinical detection of CNRF. Clinical, neurological, and imaging data were also collected. Univariable and multivariable analyses were performed to identify the clinical predictors of respiratory complications. Results: Among the 214 patients, 12 (5.6%) developed CNRF. Hypertension (91.7% vs. 55.9%, Conclusion: In patients with LMI, a combined predictive model can predict CNRF and facilitate preemptive intervention.
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