Pentahydroxyflavone and Metformin Mitigate Diabetes-Induced Hepatic Dysfunction in Gamma-Irradiated Rats Through the AMPK-SREBP-1c-SCD1 Pathway.

Hanaa F B Gaber, Fatma S M Moawed, Mohamed K Mahfouz, Esraa S A Ahmed, Omayma A R Abo-Zaid

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Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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5 authors.

Hanaa F B GaberBiochemistry and Molecular Biology Department, Faculty of Veterinary Medicine, Benha University, Al-Qalyubia, Egypt.

Fatma S M MoawedHealth Radiation Research, National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority, Cairo, Egypt.ORCID https://orcid.org/0000-0002-5792-0815

Mohamed K MahfouzBiochemistry and Molecular Biology Department, Faculty of Veterinary Medicine, Benha University, Al-Qalyubia, Egypt.

Esraa S A AhmedRadiation Biology Research, National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority, Cairo, Egypt.ORCID https://orcid.org/0000-0001-5358-4394

Omayma A R Abo-ZaidBiochemistry and Molecular Biology Department, Faculty of Veterinary Medicine, Benha University, Al-Qalyubia, Egypt.ORCID https://orcid.org/0000-0002-1752-6709

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes mellitus (DM) is a common complication among cancer patients, potentially worsening the adverse effects of radiation therapy. This study aimed to evaluate whether pentahydroxy flavone (PHF) and Metformin (MET) could mitigate liver damage associated with streptozotocin (STZ)-induced diabetes in rats exposed to gamma irradiation (IR). Diabetes was induced in rats by a single dose of STZ (35 mg/kg) and exposure to a cumulative IR dose (4 Gy). Over one month, each treatment group received either PHF (50 mg/kg) or MET (200 mg/kg). Combined treatment with PHF and MET improved lipid profiles, reduced insulin resistance, coupled with diminishing hepatic inflammation (NLRC4) and oxidative stress. Furthermore, co-administration of PHF and MET modulated the AMPK/ SREBP1c/ SCD1-related signaling, ameliorating hepatic steatosis and fibrosis. These findings suggest that PHF combined with MET's could serve as an adjuvant therapy alongside MET to protect against liver damage caused by diabetes and gamma radiation.

Indexed as

Diabetes Mellitus, ExperimentalFlavonesHypoglycemic AgentsMetforminAMP-Activated Protein KinasesAnimalsGamma RaysLiverMaleOxidative StressRatsRats, WistarSignal TransductionSterol Regulatory Element Binding Protein 1StreptozocinAMP-Activated Protein KinasesFlavonesHypoglycemic AgentsMetforminSterol Regulatory Element Binding Protein 1StreptozocinAMPK/ SREBP1c/ SCD1diabetes mellitusgamma irradiationmetforminpentahydroxy flavone

Identifiers

PMID42902859

DOI10.1002/cbdv.71801

PMCPMC13684306

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.