Evidence map›Paper›PMID 42902418›Full record

ArticleBMC research notes2026

Investigating long non-coding RNA (lncRNA) HOTAIR expression changes in ischemic stroke patients.

Alia Saberi, Niloufar Nabavi, Amirreza Ghayeghran, Zivar Salehi, Yaser Moaddabi, Mohammad Ebrahim Ghaffari, Haniyeh Haghanipor, Sara Khoshdooz, Ali Bonyad

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Article in BMC research notes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Alia SaberiNeuroscience Research Centre, Neurology Department, Poursina Hospital, Guilan University of Medical Sciences, Guilan, Iran.
Niloufar NabaviNeuroscience Research Centre, Neurology Department, Poursina Hospital, Guilan University of Medical Sciences, Guilan, Iran.
Amirreza GhayeghranNeuroscience Research Centre, Neurology Department, Poursina Hospital, Guilan University of Medical Sciences, Guilan, Iran.
Zivar SalehiDepartment of Biology, Faculty of Sciences, University of Guilan, Rasht, Iran.
Yaser MoaddabiNeuroscience Research Centre, Neurology Department, Poursina Hospital, Guilan University of Medical Sciences, Guilan, Iran.
Mohammad Ebrahim GhaffariNeuroscience Research Center, Trauma Institute, Guilan University of Medical Sciences, Rasht, Iran.
Haniyeh HaghaniporFaculty of Medicine, Guilan University of Medical Science, Rasht, Iran.
Sara KhoshdoozFaculty of Medicine, Guilan University of Medical Science, Rasht, Iran. khoshdoozsara@gmail.com.
Ali BonyadFaculty of Medicine, Guilan University of Medical Science, Rasht, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIschemic stroke (IS), a leading global health problem, is caused by interrupted blood flow in the brain, often due to clotting or artery constriction. Long non-coding RNAs (lncRNAs), particularly HOX transcript antisense intergenic RNA (HOTAIR), are pivotal in stroke pathophysiology.

aimThis study focused on the expression levels of HOTAIR lncRNA in ischemic stroke patients. METHODS AND MATERIALS: This comparative cross-sectional study with 100 participants: 50 IS patients and 50 patients without IS serving as controls. The study gathered demographic data, disease specifics, and medication history. Blood samples were analyzed for HOTAIR lncRNA expression levels.

resultsThis study showed significantly higher expression levels of HOTAIR lncRNA among IS patients compared to the control group (5.73 ± 0.75 vs. 2.35 ± 0.29; P < 0.001), with an average increase of 3.19 units compared to the control group (P < 0.001) after adjusting the independent variables. Additionally, participants with hypertension had an average increase of 0.36 units in of HOTAIR lncRNA expression compared to the control group (P = 0.041).

conclusionOur study found that HOTAIR lncRNA levels are significantly higher in IS patients and may be associated with a history of hypertension. diseases. This suggests that HOTAIR lncRNA could be a useful biomarker for stroke and related conditions.

Indexed as

Brain IschemiaIschemic StrokeRNA, Long NoncodingStrokeAgedCase-Control StudiesCross-Sectional StudiesFemaleHumansMaleMiddle AgedHOTAIR long untranslated RNA, humanRNA, Long NoncodingCerebrovascular diseaseIschemic strokeLong non-coding RNA HOTAIR

Identifiers

PMID42902418
PMCPMC13685211

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