Trial reportBMC research notes2026
Immunomodulatory effects of high versus low intensity diode laser as adjunct to non-surgical periodontal therapy in periodontitis.
Trial report in BMC research notes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePeriodontitis is characterized by a dysregulated inflammatory response mediated by proinflammatory cytokines. This study aimed to compare the immunomodulatory effects of high-intensity (DLT-H) versus low-intensity (DLT-L) diode laser therapy as adjuncts to conventional scaling and root planning (SRP) in patients with periodontitis.
resultsTwenty-seven participants contributing 81 non-adjacent periodontal sites were randomly assigned into three treatment groups: SRP alone, SRP + DLT-H, and SRP + DLT-L. Gingival crevicular fluid (GCF) was collected at baseline, 1 month, and 3 months post-treatment to quantify levels of IL-1β, IL-6, IL-8, and TNF-α. All treatment modalities led to significant reductions in pro-inflammatory cytokine levels over time (p < 0.01). DLT-H produced the most pronounced and sustained decreases, with early and long-term suppression significantly greater than both SRP alone and DLT-L. DLT-L yielded moderate yet consistent reductions across all cytokines, whereas SRP alone demonstrated limited and less durable immunomodulatory effects. Pairwise comparisons highlighted the superior efficacy of DLT-H in both early (baseline to 1 month) and late (1 to 3 months) intervals, particularly for IL-6 and TNF-α. These findings indicate that high-intensity diode laser therapy provides superior and modulatory benefits and may enhance the outcomes of nonsurgical periodontal therapy.
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