Evidence map›Paper›PMID 42902317›Full record

ArticleTrials2026

Preoperative antibiotics for mild or moderate acute cholecystitis (POMMAC): study protocol for a non-inferiority, open-label, randomized controlled trial.

Petra Terho, Ville Sallinen, Hanna Lampela, Hanna Koppatz, Henna Sammalkorpi, Panu Mentula

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Petra TerhoGastroenterological Surgery, Helsinki University Hospital and University of Helsinki, Haartmaninkatu 4, Helsinki, 00029, Finland.
Ville SallinenGastroenterological Surgery, Helsinki University Hospital and University of Helsinki, Haartmaninkatu 4, Helsinki, 00029, Finland.
Hanna LampelaGastroenterological Surgery, Helsinki University Hospital and University of Helsinki, Haartmaninkatu 4, Helsinki, 00029, Finland.
Hanna KoppatzGastroenterological Surgery, Helsinki University Hospital and University of Helsinki, Haartmaninkatu 4, Helsinki, 00029, Finland.
Henna SammalkorpiGastroenterological Surgery, Helsinki University Hospital and University of Helsinki, Haartmaninkatu 4, Helsinki, 00029, Finland.
Panu MentulaGastroenterological Surgery, Helsinki University Hospital and University of Helsinki, Haartmaninkatu 4, Helsinki, 00029, Finland. panu.mentula@hus.fi.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEvidence is lacking on the effect of preoperative antibiotic therapy on postoperative infections in acute cholecystitis. The POMMAC trial aims to investigate whether a single dose of antibiotic prophylaxis is non-inferior to continuous preoperative antibiotic therapy in terms of postoperative infections.

methodsThis is a non-inferior, open-label randomized controlled trial aiming to include 456 participants. Eligible participants with mild or moderate acute cholecystitis will be randomized at a 1:1 ratio to receive either continuous or a single dose of preoperative antibiotic prophylaxis. The primary outcome is the rate of postoperative infections within 30 days postoperatively. Secondary outcomes are rates of conversion from laparoscopic to open cholecystectomy, other postoperative complications (Clavien-Dindo), a composite outcome incorporating antibiotic-related hypersensitivity reactions, Clostridium difficile diarrhea, and yeast infections within 30 days postoperatively, and the length of stay. DISCUSSION: The POMMAC trial will provide evidence on the effect of preoperative antibiotic therapy on postoperative infections in acute cholecystitis. Abstaining from unnecessary preoperative antibiotic therapy could reduce antimicrobial resistance, adverse antibiotic-related events, and healthcare expenses.

trial registrationEU CTIS: https://euclinicaltrials.eu/search-for-clinical-trials/?lang=en&EUCT=2024-515958-24-00 protocol version 2.4. Registered on April 9th, 2025.

Indexed as

Anti-Bacterial AgentsAntibiotic ProphylaxisCholecystitis, AcuteCholecystectomy, LaparoscopicEquivalence Trials as TopicFemaleHumansPreoperative CareRandomized Controlled Trials as TopicSeverity of Illness IndexTime FactorsTreatment OutcomeAnti-Bacterial AgentsAcute cholecystitisAntibiotic resistanceLaparoscopic cholecystectomyPostoperative complicationsPostoperative infectionsPreoperative antibiotics

Identifiers

PMID42902317
PMCPMC13685358

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.