Evidence map›Paper›PMID 42902297›Full record

ArticleBiotechnology for biofuels and bioproducts2026

Formate-driven in situ CO

Mingyang Zhao, Li Wang, Yuanming Ye, Yaqin Sun, Zhilong Xiu

Abstract read
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In one paragraph

Article in Biotechnology for biofuels and bioproducts, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mingyang ZhaoMOE Key Laboratoy of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, No. 2 Linggong Road, Ganjingzi District, Dalian, 116024, Liaoning, People's Republic of China.
Li WangMOE Key Laboratoy of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, No. 2 Linggong Road, Ganjingzi District, Dalian, 116024, Liaoning, People's Republic of China.
Yuanming YeMOE Key Laboratoy of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, No. 2 Linggong Road, Ganjingzi District, Dalian, 116024, Liaoning, People's Republic of China.
Yaqin SunMOE Key Laboratoy of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, No. 2 Linggong Road, Ganjingzi District, Dalian, 116024, Liaoning, People's Republic of China. sunyaqin@dlut.edu.cn.
Zhilong XiuMOE Key Laboratoy of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, No. 2 Linggong Road, Ganjingzi District, Dalian, 116024, Liaoning, People's Republic of China.

Funding

National Key Research and Development Program of China 2022YFA0911804-03
6 · The paper itself

Abstract

backgroundSuccinic acid (SA) biosynthesis presents a promising sustainable alternative to petrochemical routes, yet industrial potential is often hampered by inefficient CO

resultsTo systematically address these bottlenecks, a synergistic metabolic engineering strategy was developed in Actinobacillus succinogenes by co-expressing the endogenous gene of formate dehydrogenase (FdoG) and the heterologous gene of phosphoenolpyruvate carboxylase (PPC). This design established a self-reinforcing metabolic loop where FdoG-mediated formate oxidation generated in situ CO

conclusionThis study establishes a sustainable and efficient platform for SA bioproduction by synergistically integrating formate metabolism-driven CO

Indexed as

Actinobacillus succinogenesCarbon flux analysisFormate-utilizationIn situ CO2 recyclingMetabolic engineeringSuccinic acid

Identifiers

PMID42902297
PMCPMC13685095

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.