ArticleBMC infectious diseases2026
TyG index and TyG-WHtR as predictors of all-cause mortality in patients with prior hepatitis A or B virus infections.
Article in BMC infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThis study aims to investigate the association between the triglyceride glucose (TyG) index and the TyG-to-waist-height ratio (TyG-WHtR) with the risk of all-cause mortality in patients with prior hepatitis A virus (HAV) or hepatitis B virus (HBV) infection.
methodThis study was a retrospective cohort study that included patients from 1999 to 2018 with available data on HAV/HBV, TyG-related indices, and survival and mortality information. Multiple imputation methods were utilized to address missing variables. A weighted multivariable Cox regression model was employed to analyze the relationship between TyG and TyG-WHtR with all-cause mortality in the study patients. Subgroup analyses were conducted based on age, gender, smoking, diabetes, cardiovascular disease, and hypertension. All analysis results were presented as hazards with a 95% confidence interval (CI).
resultsThe study included a total of 6,413 patients, of which 1,692 were dead. The follow-up period concluded in December 2019, with a total duration of 119.31 ± 1.53 months. Analysis revealed that in patients with prior HAV or HBV infection, the TyG (HR: 1.22, 95%CI: 1.10-1.36) and TyG-WHtR (HR: 1.53, 95%CI: 1.34-1.75) were associated with an increased risk of all-cause mortality. Separate studies conducted in patients with prior HAV or HBV infection also demonstrated an association between the TyG and TyG-WHtR indices with all-cause mortality (former: HR: 1.20, 95%CI: 1.07-1.34; latter: HR: 2.02, 95%CI: 1.49-2.74). Subgroup analysis results indicated that the association between TyG-WHtR and all-cause mortality was similar across age, gender, smoking, and hypertension groups (all P < 0.05).
conclusionIn patients with prior HAV or HBV infection, the TyG and TyG-WHtR indices were associated with an increased risk of all-cause mortality. This study underscores the importance of the TyG and TyG-WHtR for patients with prior viral hepatitis, potentially aiding in the improvement of health management for this group. CLINICAL TRIAL: Our research is not a clinical trial. CLINICAL TRIAL NUMBER: not applicable.
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