Evidence map›Paper›PMID 42902144›Full record

ArticleBMC cardiovascular disorders2026

Glyceamic variability is a pridictor of in-hopital and long-term mortality of patients with dilated cardiomyopathy: a 5-year retrospective cohort study.

Yang Liu, Qiwei Shen, Hongyu Liu, Gregory Y H Lip, Kui Hong

Abstract read
In one paragraph

Article in BMC cardiovascular disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yang LiuDepartment of Cardiovascular Medicine, the Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China.
Qiwei ShenMolecular Medicine of Jiangxi Key Laboratory, the Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China.
Hongyu LiuDepartment of Cardiovascular Medicine, the Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China.
Gregory Y H Lip *Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom.ORCID http://orcid.org/0000-0002-7566-1626
Kui Hong *Department of Cardiovascular Medicine, the Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China. hongkui88@163.com.

Funding

Key Project of the Second Affiliated Hospital of Nanchang University University 2022efyA05Major Program for the Prevention and Control of the Four Major Chronic Diseases 2024ZD0521500, 2024ZD0521501Molecular Medicine Jiangxi Provincial Key Laboratory Support Program 2024SSY06231National Natural Science Foundation of China 82470374
6 · The paper itself

Abstract

backgroundDilated cardiomyopathy (DCM) is a major cause of heart failure with high morbidity and mortality, yet reliable prognostic markers remain limited. Glycaemic variability (GV), reflecting fluctuations in glucose levels, has been linked to adverse cardiovascular outcomes, but its role in DCM remains uncertain.

methodsData were obtained from Beth Israel Deaconess Medical Center in Boston. We included patients with DCM as the primary diagnosis and ≥ 3 glucose measurements during hospitalization. GV was defined as the natural logarithm of the standard deviation-to-mean glucose ratio and analyzed continuously and categorically (GV ≥ 2.9 vs. <2.9). Outcomes included in-hospital, and 1-, 3-, and 5-year all-cause mortalities. Multivariable Cox regression models were adjusted for demographic, clinical, and laboratory covariates.

resultsA total of 580 patients with DCM were included (mean age 64.20 (14.80); 73% male; 55% White). Patients with GV ≥ 2.9 had higher rates of in-hospital mortality (5.6% vs. 0.7%), ICU admission (52% vs. 28%) and worse long-term outcomes, including 1-year (20% vs. 10%), 3-year (26% vs. 17%), and 5-year (29% vs. 19%) mortalities. After adjusting for demographic, clinical, and laboratory variables, Each unit increase in GV increased the risk of in-hospital [adjusted OR(aOR): 5.12, 95% CI: 1.07-31.2], ICU admission (aOR 2.59),1-year [adjusted HR (aHR) 1.84], 3-year (aHR 1.65), and 5-year (aHR 1.60) death.

conclusionGV is associated with both short- and long-term mortality in patients with DCM. The cohort median GV value of 2.9 might help stratify patients according to clinical risk.

Indexed as

Blood GlucoseCardiomyopathy, DilatedAgedBiomarkersBostonFemaleHospital MortalityHumansMaleMiddle AgedPrognosisRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsBiomarkersBlood GlucoseDilated cardiomyopathyGlycaemic variabilityMortalityRisk stratification

Identifiers

PMID42902144
PMCPMC13685292

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.