ArticleEuropean journal of epidemiology2026
Adiposity and the risk of aortic dissection incidence and mortality: results from the UK Biobank, the J-SHC study and a meta-analysis of cohort studies.
Article in European journal of epidemiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Few studies have investigated the association between adiposity and risk of aortic dissection and data is lacking on adiposity measures other than body mass index (BMI). We analyzed the association between adiposity and risk of aortic dissection in the UK Biobank, and the Japan Specific Health Checkups (J-SHC) Study, and conducted a meta-analysis of cohort studies to clarify the associations between adiposity and risk of aortic dissection. The analytical cohorts included 496,255 participants in the UK Biobank and 630,841 participants in the J-SHC Study. Multivariable Cox proportional hazards regression models were used to analyze associations between adiposity and risk of aortic dissection. PubMed and Embase were searched for relevant studies up to February 27, 2026. Random effects models were used to calculate summary relative risks (RRs) and 95% confidence intervals (CIs) for the association between adiposity and risk of aortic dissection. In the UK Biobank and J-SHC, there were 371 and 105 aortic dissections during 12.3 and 4 years follow-up, respectively. In the UK Biobank, positive associations (HRs, 95% CIs) were observed between high BMI (1.54, 1.01-2.37, p
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