Evidence map›Paper›PMID 42902073›Full record

ArticleBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine2026

Association between urinary heavy metal(loid)s exposure and dyslipidemia in children from e-waste dismantling areas.

Rui Sun, Shuhan Qu, Jieting Chen, Rongyi Kang, Jian Zhang, Xijin Xu, Lei Tan, Xia Huo

Abstract read
PubMed Publisher
In one paragraph

Article in Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rui Sun *Laboratory of Environmental Medicine and Developmental Toxicology, Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment and Climate, Jinan University, Guangzhou, 511443, Guangdong, China.
Shuhan Qu *Laboratory of Environmental Medicine and Developmental Toxicology, Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment and Climate, Jinan University, Guangzhou, 511443, Guangdong, China.
Jieting ChenLaboratory of Environmental Medicine and Developmental Toxicology, Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment and Climate, Jinan University, Guangzhou, 511443, Guangdong, China.
Rongyi KangLaboratory of Environmental Medicine and Developmental Toxicology, Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment and Climate, Jinan University, Guangzhou, 511443, Guangdong, China.
Jian ZhangLaboratory of Environmental Medicine and Developmental Toxicology, Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment and Climate, Jinan University, Guangzhou, 511443, Guangdong, China.
Xijin XuLaboratory of Environmental Medicine and Developmental Toxicology, Shantou University Medical College, Shantou, 515041, Guangdong, China.
Lei TanGuangzhou Center for Disease Control and Prevention, Guangzhou, 510440, Guangdong, China. jsutanlei@gmail.com.
Xia HuoLaboratory of Environmental Medicine and Developmental Toxicology, Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment and Climate, Jinan University, Guangzhou, 511443, Guangdong, China. xhuo@jnu.edu.cn.

Funding

National and Guangdong Natural Science Foundation of China 22376079, 2024A1515013294
6 · The paper itself

Abstract

To assess temporal trends of urinary heavy metal(loid)s burden and lipid levels, and explore the single and joint associations of heavy metal(loid)s exposure with lipid profiles among children in Guiyu, a typical e-waste dismantling area in China. Based on 2016 and 2024 surveys in Guiyu, 197 children (aged 3-7) were enrolled. Urinary concentrations of 13 heavy metal(loid)s were determined using inductively coupled plasma mass spectrometry (ICP-MS). Serum lipid parameters including total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were measured, and non-high-density lipoprotein cholesterol (non-HDL-C) was calculated. To investigate the independent and combined associations between metals and blood lipid profiles, multiple linear regression and Bayesian kernel machine regression (BKMR) models were employed. Urinary concentrations of Chromium (Cr), Nickel (Ni), Copper (Cu), Cadmium (Cd), and Lead (Pb) in 2024 were significantly lower than those in 2016 (all P < 0.05). In adjusted models, Manganese (Mn), Cobalt (Co), Cd, and Pb were positively associated with TC and non-HDL-C, while Cd and Pb were negatively associated with HDL-C (all P < 0.05). BKMR confirmed a significant joint positive effect of a 12-metal mixture on TC and non-HDL-C, and a negative effect on HDL-C. Despite decreased individual metal levels over the eight-year interval, the biological risk from co‑exposure to these metals remains a critical concern These findings highlight the need for vigilance regarding the synergistic cardiovascular toxicity of heavy metals on pediatric lipid homeostasis.

Indexed as

ChildrenDyslipidemiaE-wasteHeavy metal(loid)s

Identifiers

PMID42902073

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.