Evidence map›Paper›PMID 42901989›Full record

SynthesisInternational journal of colorectal disease2026

Prehabilitation for colon cancer surgery: a systematic review of quality-of-life outcomes and a feasibility study.

Michelle V Stadelhofer, Helene R Dalby, Anne Thyø, Katrine J Emmertsen

Abstract readSystematic Review
In one paragraph

Synthesis in International journal of colorectal disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Michelle V StadelhoferDepartment of Abdominal Surgery, Regional Hospital Randers, Randers, Denmark. Stadelhofer.m@gmail.com.ORCID http://orcid.org/0000-0003-2422-6904
Helene R DalbyDepartment of Abdominal Surgery, Regional Hospital Randers, Randers, Denmark.ORCID http://orcid.org/0000-0001-8923-314X
Anne ThyøDepartment of Abdominal Surgery, Regional Hospital Randers, Randers, Denmark.ORCID http://orcid.org/0000-0003-0969-7177
Katrine J EmmertsenDepartment of Abdominal Surgery, Regional Hospital Randers, Randers, Denmark.ORCID http://orcid.org/0000-0001-6153-4346

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the feasibility of short-term prehabilitation and its impact on quality of life in patients with colorectal cancer through a systematic review and a feasibility study.

methodsThe systematic review was conducted in accordance with the PRISMA guidelines. PubMed, PubPsych, CINAHL, EMBASE, Web of Science and EBSCOhost were searched for studies evaluating quality of life in colorectal cancer patients undergoing prehabilitation. We conducted a prospective non-randomised interventional feasibility study, with a 2-week post-surgery follow-up, enrolling patients diagnosed with colon cancer.

resultsThe systematic review included six studies from 517 unique records for final analysis. Among six studies, evidence for quality-of-life benefits of prehabilitation was conflicting but predominantly favourable, with generally low-to-moderate study quality and substantial heterogeneity. In the feasibility study, 110 patients were eligible for inclusion; 70 (64%) were included, and 63 completed the entire study. Of the 32 patients in the intervention group, compliance > 80% was observed in 66% (nutrition) and 88% (physical activity) of patients, with a median compliance of 100% for both. Quality-of-life outcomes were explored as secondary measures and showed potential favourable trends following prehabilitation.

conclusionEvidence on the effect of prehabilitation on quality of life in colorectal cancer remains inconsistent; our feasibility study shows that short-term multimodal prehabilitation is feasible and supports the need for adequately powered trials.

Indexed as

Colonic NeoplasmsPreoperative ExerciseQuality of LifeColorectal Surgical ProceduresFeasibility StudiesHumansTreatment OutcomeColorectal cancerFeasibilityPrehabilitationPROMSQuality of life (QoL)Systematic review

Identifiers

PMID42901989
PMCPMC13683530

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.