Evidence map›Paper›PMID 42900997›Full record

ArticleRedox biology2026

CO-mediated restoration of mitochondrial redox homeostasis contributes to alleviating multiple programmed cell deaths in hepatic I/R injury.

Jiayu Li, Mengzhu Xu, Qiang Zhou, Hanjing Ni, Chengge Shi, Tianci Zuo, Lingjun Zhang, Hongyang Lu, Wei He, Li Yu and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Redox biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jiayu LiSchool and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, 325027, China.
Mengzhu XuSchool and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, 325027, China.
Qiang ZhouDepartment of Neurosurgery, Shanghai Tenth People's Hospital of Tongji University, Shanghai, 200072, China. Electronic address: zqreadmore@163.com.
Hanjing NiDepartment of Gastroenterology, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325024, China.
Chengge ShiSchool and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, 325027, China.
Tianci ZuoSchool and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, 325027, China.
Lingjun ZhangSchool and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, 325027, China.
Hongyang LuSchool and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, 325027, China.
Wei HeSchool and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, 325027, China.
Li YuSchool and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, 325027, China.
Quazi T H ShubhraInstitute of Chemistry, University of Silesia in Katowice, Szkolna 9, Katowice, 40-006, Poland.
Changlong XuDepartment of Gastroenterology, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325024, China. Electronic address: xchlong@163.com.
Xiaojun CaiSchool and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, 325027, China. Electronic address: cxj520118@njtech.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatic ischemia-reperfusion injury (HIRI) remains a life-threatening complication in liver surgery and transplantation with no clinically approved therapy. Here we develop a hyaluronic acid-modified, ROS-responsive nanoformulation (CPs@HA) that enables controllable delivery of carbon monoxide (CO) specifically to injured liver tissue. We show that mitochondrial dysfunction is closely associated with three distinct cell death pathways (ferroptosis, cuproptosis, and disulfidptosis) that occur in parallel during HIRI. CPs@HA restores mitochondrial homeostasis through activating the AMPK-SIRT1-PGC-1α axis and restoring Ca

Indexed as

Controllable carbon monoxide deliveryCuproptosisDisulfidptosisFerroptosisHepatic ischemia–reperfusion injuryMitochondrial homeostasis

Identifiers

PMID42900997

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.