IL1RAP promotes EMT and metastatic phenotypes in papillary thyroid carcinoma and is associated with PI3K/AKT signaling activation.

Yongkui Zhao, Yunlei Shao, Zhiwei Guo, Mingyue Guo

Abstract read

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Article in Medical oncology (Northwood, London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

4 authors.

Yongkui ZhaoDepartment of General Surgery, Chifeng Municipal Hospital, Inner Mongolia Medical University, No. 1 Zhaowuda Road, Hongshan District, Chifeng, Inner Mongolia, 024000, P.R. China.

Yunlei ShaoDepartment of General Surgery, Chifeng Municipal Hospital, Inner Mongolia Medical University, No. 1 Zhaowuda Road, Hongshan District, Chifeng, Inner Mongolia, 024000, P.R. China.

Zhiwei GuoDepartment of General Surgery, Chifeng Municipal Hospital, Inner Mongolia Medical University, No. 1 Zhaowuda Road, Hongshan District, Chifeng, Inner Mongolia, 024000, P.R. China.

Mingyue GuoDepartment of General Surgery, Chifeng Municipal Hospital, Inner Mongolia Medical University, No. 1 Zhaowuda Road, Hongshan District, Chifeng, Inner Mongolia, 024000, P.R. China. myguo@cmu.edu.cn.

Funding

Joint Project of Inner Mongolia Medical University grant numbers: YKD2023LH015

6 · The paper itself

Abstract

Although papillary thyroid carcinoma (PTC) usually follows an indolent course, lymph node metastasis and locally advanced disease remain clinically important challenges. This study evaluated interleukin-1 receptor accessory protein (IL1RAP) in PTC using pan-cancer datasets, TCGA/GEO thyroid cancer cohorts, and in vitro validation. IL1RAP was upregulated in PTC tissues and cell lines, and higher IL1RAP expression was associated with advanced pathologic stage, lymph node metastasis, extrathyroidal extension, and unfavorable prognostic indicators. Functional assays showed that IL1RAP overexpression increased PTC cell proliferation, migration, invasion, and EMT-like changes, whereas transient IL1RAP silencing produced the opposite pattern. Bioinformatic enrichment and western blot analyses indicated that these cellular effects were accompanied by increased p-AKT with minimal change in total AKT, suggesting possible involvement of PI3K/AKT-related signaling. To our knowledge, this is the first systematic analysis linking IL1RAP to EMT-associated aggressive behavior in PTC. IL1RAP may represent a candidate biomarker associated with aggressive clinicopathological features, while its diagnostic/prognostic utility and therapeutic potential require further validation.

Indexed as

Epithelial-Mesenchymal TransitionInterleukin-1 Receptor Accessory ProteinPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktThyroid Cancer, PapillaryThyroid NeoplasmsBiomarkers, TumorCell Line, TumorCell MovementCell ProliferationFemaleGene Expression Regulation, NeoplasticHumansLymphatic MetastasisMaleMiddle AgedBiomarkers, TumorIL1RAP protein, humanInterleukin-1 Receptor Accessory ProteinPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktBiomarkerEpithelial-mesenchymal transitionIL1RAPImmune infiltrationMetastasisPapillary thyroid carcinomaPI3K/AKT signaling

Identifiers

PMID42900448

DOI10.1186/s12957-026-04242-5

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.