Evidence map›Paper›PMID 42900420›Full record

ArticleJournal of physiology and biochemistry2026

GSDMD palmitoylation induces acinar cell pyroptosis via promoting GSDMD-N oligomerization to aggravate hyperlipidemic acute pancreatitis.

Hongwei Xu, Chunlin Liu, Dajun Wang, Lu Zhang, Yanan Peng, Liang Wang

Abstract read
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Article in Journal of physiology and biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Hongwei XuDepartment of Hepatobiliary, Pancreatic and Splenic Surgery, The First Affiliated Hospital of Xinxiang Medical University, No 88 Jiankang Road, Xinxiang, 453100, China. doctorxuhongwei@163.com.
Chunlin LiuDepartment of Hepatobiliary, Pancreatic and Splenic Surgery, The First Affiliated Hospital of Xinxiang Medical University, No 88 Jiankang Road, Xinxiang, 453100, China.
Dajun WangDepartment of Hepatobiliary, Pancreatic and Splenic Surgery, The First Affiliated Hospital of Xinxiang Medical University, No 88 Jiankang Road, Xinxiang, 453100, China.
Lu ZhangDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Xinxiang Medical University, No 88 Jiankang Road, Xinxiang, 453100, China.
Yanan PengDepartment of Hepatobiliary, Pancreatic and Splenic Surgery, The First Affiliated Hospital of Xinxiang Medical University, No 88 Jiankang Road, Xinxiang, 453100, China.
Liang WangDepartment of Hepatobiliary, Pancreatic and Splenic Surgery, The First Affiliated Hospital of Xinxiang Medical University, No 88 Jiankang Road, Xinxiang, 453100, China.

Funding

2022 Doctoral Research Project Start-up Fund 11132
6 · The paper itself

Abstract

Pancreatic acinar cell pyroptosis played a key role in acute pancreatitis (AP), while the underlying molecular mechanisms were unclear. In this study, hyperlipidemic acute pancreatitis (HLAP) model mice and primary acinar cells were employed for the in vivo and in vitro experiments, respectively. Western blot was employed to assess Gasdermin D-N-terminal pore-forming domain (GSDMD-N) oligomerization; Flow cytometry was employed to assess cell pyroptosis; Immunofluorescence was performed to assess GSDMD-N location in the cytoplasm; HE and TUNEL staining were employed to assess the pathological changes and cell apoptosis of pancreatic tissues. Palmitic acid levels were elevated in serum and pancreatic tissues of HLAP mice, palmitoyltransferase Zinc Finger DHHC Domain-Containing Protein 13 (ZDHHC13) and ZDHHC15 expression levels were markedly increased in primary acinar cells of HLAP mice. Acinar cells of HLAP mice exhibited the increased pyroptosis, which was evidenced by the increased cleaved-caspase-1 and GSDMD-N protein levels, Interleukin (IL)-1β, IL-18, and lactate dehydrogenase (LDH) release, GSDMD-N oligomerization, and caspase-1

Indexed as

Acinar CellsHyperlipidemiasIntracellular Signaling Peptides and ProteinsPancreatitisPhosphate-Binding ProteinsPyroptosisAnimalsDisease Models, AnimalGasderminsLipoylationMaleMiceMice, Inbred C57BLPalmitic AcidPancreasProtein MultimerizationGasderminsGsdmd protein, mouseIntracellular Signaling Peptides and ProteinsPalmitic AcidPhosphate-Binding ProteinsCell pyroptosisGSDMD-N oligomerizationHyperlipidemic acute pancreatitisPalmitic acidZDHHC15

Identifiers

PMID42900420

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