ReviewOdontology2026
Cellular senescence and the SASP in the oral-metabolic axis: a putative link between periodontitis and type 2 diabetes mellitus.
Review in Odontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Periodontitis and type 2 diabetes mellitus (T2DM) are chronic inflammatory disorders with a bidirectional clinical association. Although microbial, immune, and metabolic mechanisms contribute to this relationship, they do not fully explain the persistence of inflammation and defective tissue repair. Cellular senescence and the senescence-associated secretory phenotype (SASP) may provide an additional framework for understanding this interaction. Within periodontal tissues, sustained microbial and metabolic stress may promote senescence-associated changes that disturb local immune regulation, tissue regeneration and bone homeostasis. These processes could interact with microbial dysbiosis and systemic inflammation as part of the oral-metabolic axis. However, the available evidence remains uneven. Diabetes-related stress can promote senescence-like changes in periodontal tissues, whereas direct evidence that periodontal senescence impairs distant metabolic organs is limited. This review examines the evidence linking cellular senescence to periodontal inflammation and T2DM, and discusses the emerging preclinical evidence for targeting senescent cells and the SASP.
Indexed as
Identifiers
42900330What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.