Evidence map›Paper›PMID 42899793›Full record

ArticleAnnals of clinical and translational neurology2026

Incident Comorbid Diabetes and Outcomes in Multiple Sclerosis: An English Population-Based Cohort Study.

Yolanda Lau, Sedigheh Zabihi, Morghan Hartmann, Georgina Mathlin, Sube Banerjee, Ebaa Marouf, Clare Hadley, Claudia Cooper, Ruth Dobson

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Article in Annals of clinical and translational neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Yolanda LauWolfson Institute of Population Health, Queen Mary University of London, London, UK.ORCID https://orcid.org/0009-0005-2896-6127
Sedigheh ZabihiWolfson Institute of Population Health, Queen Mary University of London, London, UK.ORCID https://orcid.org/0000-0002-2770-0862
Morghan HartmannWolfson Institute of Population Health, Queen Mary University of London, London, UK.ORCID https://orcid.org/0000-0003-4386-9040
Georgina MathlinWolfson Institute of Population Health, Queen Mary University of London, London, UK.ORCID https://orcid.org/0000-0001-6475-9006
Sube BanerjeeFaculty of Medicine and Health Sciences, University of Nottingham, Nottingham, UK.ORCID https://orcid.org/0000-0002-8083-7649
Ebaa MaroufDeNPRU-QM Patient and Public Engagement Group, London, UK.
Clare HadleyDeNPRU-QM Patient and Public Engagement Group, London, UK.
Claudia CooperWolfson Institute of Population Health, Queen Mary University of London, London, UK.ORCID https://orcid.org/0000-0002-2777-7616
Ruth DobsonWolfson Institute of Population Health, Queen Mary University of London, London, UK.ORCID https://orcid.org/0000-0002-2993-585X

Funding

National Institute for Health and Care Research NIHR206110
6 · The paper itself

Abstract

objectiveTo compare the incidence of diabetes mellitus and its associations with hospitalisation and mortality in adults with multiple sclerosis (MS) and matched controls.

methodsUsing English primary care data from the Clinical Practice Research Datalink, linked to hospital and mortality records, we matched adults with MS with up to 10 controls without MS by age, sex and practice. We excluded individuals with pre-existing diabetes mellitus. Outcomes included all-cause hospitalisation (number and duration) and mortality. We used Poisson, negative binomial, linear and Cox proportional hazards models, adjusting for demographic and socioeconomic factors, with interaction terms for ethnicity, deprivation and urbanity.

resultsWe included 47,247 individuals with MS and 458,951 matched controls. Over a mean follow-up of 15.2 years, people with MS had a higher incidence of diabetes mellitus (adjusted incidence rate ratio = 1.16, 95% confidence interval 1.11-1.21). Among people with MS, incident diabetes mellitus was associated with higher hospitalisation rates (adjusted incidence rate ratio = 1.52, 1.42-1.64), longer hospitalisation duration (median 12 vs. 2 days) and increased mortality (adjusted hazard ratio = 1.41, 1.31-1.49). Similar patterns were observed among controls. The association between diabetes mellitus and increased hospitalisation was stronger in rural areas among those with MS and in White groups among controls.

interpretationMS was associated with a higher incidence of diabetes mellitus, which was in turn associated with greater hospitalisation and mortality. These findings may support consideration of equitable screening, prevention and management of diabetes mellitus in people living with MS.

Indexed as

comorbiditydiabeteshealth inequalitiesmultiple sclerosis

Identifiers

PMID42899793
PMCPMC13682410

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