Evidence map›Paper›PMID 42899469›Full record

ArticleeLife2026

An integrated human forebrain organoid reveals microglia-mediated CD8

Yilin Feng, Feifei Yu, Jiyuan Tang, Honghui Zheng, Zitian Wang, Shaohua Ma

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yilin Feng *Institute of Biopharmaceutical and Health Engineering (iBHE), Tsinghua Shenzhen International Graduate School (SIGS), Tsinghua University, Shenzhen, China.ORCID https://orcid.org/0000-0002-7806-339X
Feifei Yu *Institute of Biopharmaceutical and Health Engineering (iBHE), Tsinghua Shenzhen International Graduate School (SIGS), Tsinghua University, Shenzhen, China.
Jiyuan Tang *Institute of Biopharmaceutical and Health Engineering (iBHE), Tsinghua Shenzhen International Graduate School (SIGS), Tsinghua University, Shenzhen, China.
Honghui ZhengInstitute of Biopharmaceutical and Health Engineering (iBHE), Tsinghua Shenzhen International Graduate School (SIGS), Tsinghua University, Shenzhen, China.
Zitian WangInstitute of Biopharmaceutical and Health Engineering (iBHE), Tsinghua Shenzhen International Graduate School (SIGS), Tsinghua University, Shenzhen, China.
Shaohua MaInstitute of Biopharmaceutical and Health Engineering (iBHE), Tsinghua Shenzhen International Graduate School (SIGS), Tsinghua University, Shenzhen, China.ORCID https://orcid.org/0000-0002-4995-2032

Funding

Key-Area Research and Development Program of Guangdong 2023B0909020003National Key Research and Development Program of China 2024YFA0919800National Natural Science Foundation of China 32371470Shenzhen Medical Academy of Research and Translation B2402009Shenzhen Natural Science Foundation JCYJ20241202123909013Shenzhen Natural Science Foundation QNXMA20250701093300001
6 · The paper itself

Abstract

Genetic evidence implicates immune dysfunction in Alzheimer's disease (AD), yet the neuroimmune mechanisms operating in human tissue remain poorly defined. Here, we establish a modular human forebrain organoid platform that systematically integrates human induced pluripotent stem cell-derived microglia and CD8

Indexed as

Alzheimer DiseaseCD8-Positive T-LymphocytesMicrogliaOrganoidsProsencephalonAmyloid beta-PeptidesHumansInduced Pluripotent Stem CellsAmyloid beta-PeptidesAlzheimer's diseaseCCL5-CCR5 signalingCD8+ T cellsmicroglianeuroinflammationneuroscienceorganoidregenerative medicinestem cells

Identifiers

PMID42899469
PMCPMC13682712

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.