Evidence map›Paper›PMID 42899383›Full record

ArticleGeriatrics & gerontology international2026

Nocturia ≥ 3/Night and 5-Year Fragility Fracture Risk in Older Urology Outpatients.

Kunihisa Nezu, Maiko Yamashita, Shingo Myoen, Naoki Kawamorita

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Article in Geriatrics & gerontology international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Kunihisa NezuDepartment of Urology, Hachinohe City Hospital, Aomori, Japan.ORCID https://orcid.org/0000-0002-4238-866X
Maiko YamashitaDepartment of Urology, Hachinohe City Hospital, Aomori, Japan.
Shingo MyoenDepartment of Urology, Hachinohe City Hospital, Aomori, Japan.
Naoki KawamoritaDepartment of Urology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo evaluate whether nocturia ≥ 3/night stratifies 5-year fragility-fracture risk in older urology outpatients and to explore its prognostic performance alongside the N-QoL and IPSS.

methodsWe conducted a retrospective cohort study of urology outpatients aged ≥ 65 years at Hachinohe City Hospital, Japan, between 2015 and 2024. After exclusion of patients with prior fragility fracture, bone metastasis, or pathological fracture, and application of a 3-month landmark, 2290 participants were included. The primary outcome was first non-pathological fragility fracture. Bone metastasis and death were treated as competing events. Fine-Gray subdistribution hazard models were adjusted for age, sex, hypertension, and diabetes. To complement effect estimates, standardized 5-year cumulative incidence was estimated using model-based standardization.

resultsOver a median follow-up of 48.1 months, 98 fragility fractures occurred; 42 bone metastases and 18 deaths were treated as competing events. Nocturia ≥ 3/night was associated with higher fracture risk than nocturia < 3/night (subdistribution hazard ratio [sHR] 2.11, 95% confidence interval [CI] 1.41-3.17). Impaired N-QoL was also associated with higher risk (sHR 1.92, 95% CI 1.12-3.30), whereas severe IPSS showed a weaker association (sHR 1.79, 95% CI 1.00-3.22). The standardized 5-year fracture risk was 9.8% for nocturia ≥ 3/night and 4.8% for nocturia < 3/night, corresponding to an absolute difference of 5.0 percentage points.

conclusionsNocturia ≥ 3/night was associated with higher 5-year fragility-fracture risk and may prompt consideration of falls and bone-health assessment in older urology outpatients.

Indexed as

NocturiaOsteoporotic FracturesAgedAged, 80 and overFemaleHumansIncidenceJapanMaleOutpatientsPrognosisRetrospective StudiesRisk AssessmentRisk Factorscompeting riskfragility fracturenocturiaolder adultsurology outpatients

Identifiers

PMID42899383
PMCPMC13681241

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