ArticleCirculation2026
Multimodal
Abstract read
In one paragraph
Article in Circulation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
29 authors.
M Lorena HarveyDepartment of Medicine (M.L.H., M.C.L., J.E.S., T.A.A., A.M., R.K., T.Y., M.E.C., D.J.B., J.L.A., M.R.F., M.A.B., E.S., G.D., B.M.K., B.C.K., D.M.R., A.M.G.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0009-0008-4752-6081
Ellen OsbornVanderbilt Human Genetics Program, Vanderbilt University, Nashville, TN (E.O., R.E.D.).ORCID 0009-0007-8351-0741
Megan C LancasterDepartment of Medicine (M.L.H., M.C.L., J.E.S., T.A.A., A.M., R.K., T.Y., M.E.C., D.J.B., J.L.A., M.R.F., M.A.B., E.S., G.D., B.M.K., B.C.K., D.M.R., A.M.G.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0002-2697-3762
Jeremy E SmithDepartment of Medicine (M.L.H., M.C.L., J.E.S., T.A.A., A.M., R.K., T.Y., M.E.C., D.J.B., J.L.A., M.R.F., M.A.B., E.S., G.D., B.M.K., B.C.K., D.M.R., A.M.G.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0009-0004-1958-5253
Qianyi ShenMark Cowley Lidwill Research Program in Cardiac Electrophysiology, Victor Chang Cardiac Research Institute, Darlinghurst, Australia (Q.S., J.I.V.).
Temidayo A AbeDepartment of Medicine (M.L.H., M.C.L., J.E.S., T.A.A., A.M., R.K., T.Y., M.E.C., D.J.B., J.L.A., M.R.F., M.A.B., E.S., G.D., B.M.K., B.C.K., D.M.R., A.M.G.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0001-8371-2000
Ruoyi CaiStanford Center for Inherited Cardiovascular Disease, Division of Cardiovascular Medicine, Department of Medicine, Stanford School of Medicine, Palo Alto, CA (R.C., J.W.O., V.N.P., E.A.A.).ORCID 0009-0006-0322-3375
Ayesha MuhammadDepartment of Medicine (M.L.H., M.C.L., J.E.S., T.A.A., A.M., R.K., T.Y., M.E.C., D.J.B., J.L.A., M.R.F., M.A.B., E.S., G.D., B.M.K., B.C.K., D.M.R., A.M.G.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0003-0870-2923
Rose KannankerilDepartment of Medicine (M.L.H., M.C.L., J.E.S., T.A.A., A.M., R.K., T.Y., M.E.C., D.J.B., J.L.A., M.R.F., M.A.B., E.S., G.D., B.M.K., B.C.K., D.M.R., A.M.G.), Vanderbilt University Medical Center, Nashville, TN.
Tao YangDepartment of Medicine (M.L.H., M.C.L., J.E.S., T.A.A., A.M., R.K., T.Y., M.E.C., D.J.B., J.L.A., M.R.F., M.A.B., E.S., G.D., B.M.K., B.C.K., D.M.R., A.M.G.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0003-2536-7522
Maria E CalandranisDepartment of Medicine (M.L.H., M.C.L., J.E.S., T.A.A., A.M., R.K., T.Y., M.E.C., D.J.B., J.L.A., M.R.F., M.A.B., E.S., G.D., B.M.K., B.C.K., D.M.R., A.M.G.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0009-0006-4107-6177
Daniel J BlackwellDepartment of Medicine (M.L.H., M.C.L., J.E.S., T.A.A., A.M., R.K., T.Y., M.E.C., D.J.B., J.L.A., M.R.F., M.A.B., E.S., G.D., B.M.K., B.C.K., D.M.R., A.M.G.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0001-6619-1792
Richard E DolderVanderbilt Human Genetics Program, Vanderbilt University, Nashville, TN (E.O., R.E.D.).ORCID 0009-0007-3243-8946
Jessa L AldridgeDepartment of Medicine (M.L.H., M.C.L., J.E.S., T.A.A., A.M., R.K., T.Y., M.E.C., D.J.B., J.L.A., M.R.F., M.A.B., E.S., G.D., B.M.K., B.C.K., D.M.R., A.M.G.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0002-6071-9581
Matthew R FlemingDepartment of Medicine (M.L.H., M.C.L., J.E.S., T.A.A., A.M., R.K., T.Y., M.E.C., D.J.B., J.L.A., M.R.F., M.A.B., E.S., G.D., B.M.K., B.C.K., D.M.R., A.M.G.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0002-1875-7445
Marcia A BlairDepartment of Medicine (M.L.H., M.C.L., J.E.S., T.A.A., A.M., R.K., T.Y., M.E.C., D.J.B., J.L.A., M.R.F., M.A.B., E.S., G.D., B.M.K., B.C.K., D.M.R., A.M.G.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0009-0004-2891-3992
Eduardo SoriaDepartment of Medicine (M.L.H., M.C.L., J.E.S., T.A.A., A.M., R.K., T.Y., M.E.C., D.J.B., J.L.A., M.R.F., M.A.B., E.S., G.D., B.M.K., B.C.K., D.M.R., A.M.G.), Vanderbilt University Medical Center, Nashville, TN.
Jack W O'SullivanStanford Center for Inherited Cardiovascular Disease, Division of Cardiovascular Medicine, Department of Medicine, Stanford School of Medicine, Palo Alto, CA (R.C., J.W.O., V.N.P., E.A.A.).ORCID 0000-0003-3629-2546
Giovanni DavogusttoDepartment of Medicine (M.L.H., M.C.L., J.E.S., T.A.A., A.M., R.K., T.Y., M.E.C., D.J.B., J.L.A., M.R.F., M.A.B., E.S., G.D., B.M.K., B.C.K., D.M.R., A.M.G.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0003-2771-6466
Brett M KronckeDepartment of Medicine (M.L.H., M.C.L., J.E.S., T.A.A., A.M., R.K., T.Y., M.E.C., D.J.B., J.L.A., M.R.F., M.A.B., E.S., G.D., B.M.K., B.C.K., D.M.R., A.M.G.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0001-6215-0803
Calum A MacRaeCardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (C.A.M.).ORCID 0000-0001-5181-2664
Bjorn C KnollmannDepartment of Medicine (M.L.H., M.C.L., J.E.S., T.A.A., A.M., R.K., T.Y., M.E.C., D.J.B., J.L.A., M.R.F., M.A.B., E.S., G.D., B.M.K., B.C.K., D.M.R., A.M.G.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0003-4956-9735
Frederick P RothDepartment of Computational and Systems Biology, University of Pittsburgh School of Medicine, PA (F.P.R.).ORCID 0000-0002-6628-649X
Victoria N ParikhStanford Center for Inherited Cardiovascular Disease, Division of Cardiovascular Medicine, Department of Medicine, Stanford School of Medicine, Palo Alto, CA (R.C., J.W.O., V.N.P., E.A.A.).ORCID 0000-0002-5138-5559
Euan A AshleyStanford Center for Inherited Cardiovascular Disease, Division of Cardiovascular Medicine, Department of Medicine, Stanford School of Medicine, Palo Alto, CA (R.C., J.W.O., V.N.P., E.A.A.).ORCID 0000-0001-9418-9577
Jamie I VandenbergMark Cowley Lidwill Research Program in Cardiac Electrophysiology, Victor Chang Cardiac Research Institute, Darlinghurst, Australia (Q.S., J.I.V.).ORCID 0000-0002-3859-3716
Chai-Ann NgSchool of Clinical Medicine, University of New South Wales, Sydney, Australia (J.I.V., C.-A.N.).ORCID 0000-0002-3120-5450
Dan M Roden *Department of Medicine (M.L.H., M.C.L., J.E.S., T.A.A., A.M., R.K., T.Y., M.E.C., D.J.B., J.L.A., M.R.F., M.A.B., E.S., G.D., B.M.K., B.C.K., D.M.R., A.M.G.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0002-6302-0389
Andrew M Glazer *Department of Medicine (M.L.H., M.C.L., J.E.S., T.A.A., A.M., R.K., T.Y., M.E.C., D.J.B., J.L.A., M.R.F., M.A.B., E.S., G.D., B.M.K., B.C.K., D.M.R., A.M.G.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0002-3938-4713
Funding
Vanderbilt Clinical Oncology Research Career Development ProgramK12CA090625 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Debra L. Friedman, Paula Jill Hurley · 2001 to 2026
$16.9MSystematically mapping variant effects for cardiovascular genesR01HL164675 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ASHLEY, EUAN A, RODEN, DAN M · 2022 to 2025
$8.1MIntegrating KCNH2 Variant-Specific Features and Heterozygote Phenotypes to Estimate Long QT PenetranceR01HL160863 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Brett M Kroncke · 2022 to 2026
$2.9MHigh-throughput discovery of disease-associated ion channel variantsR35GM150465 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Andrew M. Glazer · 2023 to 2026
$1.8MA pipeline for identifying disease-causing variants in transmembrane proteinsR00HG010904 · NHGRI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GLAZER, ANDREW M. · 2022 to 2024
$737kA high-throughput, multimodal strategy to improve variant classificationK08HG014001 · NHGRI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Megan Lancaster · 2025 to 2026
$347kNCI NIH HHS K12 CA090625NHGRI NIH HHS K08 HG014001NHGRI NIH HHS R00 HG010904NHLBI NIH HHS R01 HL160863NHLBI NIH HHS R01 HL164675NIGMS NIH HHS R35 GM150465
Abstract
backgroundVariants in the ion channel gene
methodsWe generated a nearly comprehensive variant library of 13 403 protein-coding variants in
resultsAcross the 4 assays, we generated 49 305 functional measurements of
conclusionsThis comprehensive
Indexed as
arrhythmiaarrhythmias, cardiacgenetic testingKCNQ1 potassium channellong QT syndrome
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.