ArticleCureus2026
Oral Kaposi Sarcoma With Clinical Features Suggestive of Concurrent Multicentric Castleman Disease in Advanced AIDS.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Kaposi sarcoma (KS) is an AIDS-defining malignancy associated with advanced HIV infection and human herpesvirus-8 (HHV-8). We report a case of biopsy-proven oral KS in a 31-year-old patient with advanced AIDS and clinical features suggestive of concurrent multicentric Castleman disease (MCD), highlighting the diagnostic complexity of overlapping AIDS-related conditions. We describe the clinical presentation, diagnostic evaluation, imaging findings, histopathologic features, and management of a 31-year-old man with advanced AIDS and antiretroviral nonadherence presenting with constitutional, gastrointestinal, and neurologic symptoms. Laboratory evaluation demonstrated profound immunosuppression, elevated HIV viral load, cytopenias, hepatocellular injury, and markedly elevated inflammatory markers. Physical examination revealed violaceous oral and cutaneous lesions. Infectious evaluation was largely unrevealing, while imaging demonstrated diffuse lymphadenopathy and inflammatory colitis. Histopathologic examination of an oral lesion confirmed KS with HHV-8 positivity. The combination of diffuse lymphadenopathy, systemic inflammation, and cytopenias raised concern for concurrent MCD. The patient was restarted on antiretroviral therapy (ART) and initiated on trimethoprim-sulfamethoxazole for
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