Evidence map›Paper›PMID 42899189›Full record

ArticleMyeloid cells2026

Scalable generation of pure CD103

Sukriti Sharma, Fiona Flynn, Brian Capaldo, Ronald Holewinski, Qingrong Chen, Daoud Meerzaman, Thorkell Andresson, Christian T Mayer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Myeloid cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sukriti SharmaExperimental Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Bethesda, MD 20892, USA.
Fiona FlynnExperimental Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Bethesda, MD 20892, USA.
Brian CapaldoComputational Genomics and Bioinformatics Branch, National Cancer Institute, National Institutes of Health, Frederick, MD 20850, USA.
Ronald HolewinskiProtein and Metabolite Characterization Core, Cancer Research and Technology Program, Frederick National Laboratory for Cancer Research, National Institutes of Health, Frederick, MD 21701, USA.
Qingrong ChenComputational Genomics and Bioinformatics Branch, National Cancer Institute, National Institutes of Health, Frederick, MD 20850, USA.
Daoud MeerzamanComputational Genomics and Bioinformatics Branch, National Cancer Institute, National Institutes of Health, Frederick, MD 20850, USA.
Thorkell AndressonProtein and Metabolite Characterization Core, Cancer Research and Technology Program, Frederick National Laboratory for Cancer Research, National Institutes of Health, Frederick, MD 21701, USA.
Christian T MayerExperimental Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Bethesda, MD 20892, USA.

Funding

The role of apoptosis in B lymphocyte biologyZIABC011975 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI MAYER, CHRISTIAN · 2020 to 2025
$5.2M
Intramural NIH HHS Z99 CA999999Intramural NIH HHS ZIA BC011975
6 · The paper itself

Abstract

Aims: Conventional type 1 dendritic cells (cDC1) specialize in cross-presentation and interleukin-12 production and are critical for immunity against intracellular pathogens and tumors, but remain rare Methods: Mouse bone marrow cells were cultured in defined medium with recombinant FLT3L, low-dose GM-CSF, and Kit ligand (KitL) to generate induced cDC1 (iDC1). Phenotypic, transcriptomic, proteomic, phospho-proteomic, and functional analyses were performed and compared with established BMDC methods and Results: iDC1 cultures enabled scalable generation of an estimated 1.5 × 10 Conclusion: iDC1 cultures are a scalable platform for studying cDC1 biology and may facilitate development and preclinical evaluation of cDC1-based immunotherapeutic strategies.

Indexed as

BRD4CD103+ DCcDC1Cross-presentationGM-CSFiDC1IL-12p40STAT5

Identifiers

PMID42899189
PMCPMC13679636

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.