ArticleKidney medicine2026
Sleep Disturbances in Chronic Kidney Disease - The CKD-REIN Cohort Study.
Article in Kidney medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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14 authors.
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Abstract
Rationale & Objective: Insomnia and excessive daytime sleepiness (EDS) are common in patients with chronic kidney disease (CKD), but their determinants are poorly understood. We analyzed multiple factors likely to affect sleep with the aim of disentangling the contributions of CKD markers and symptoms from those of social factors, lifestyle, comorbid conditions, and drug-induced effects, with the latter 2 highly prevalent in this population. Study Design: Prospective cohort study. Setting & Participants: In total, 2,765 patients with CKD stages 2-5 not receiving dialysis (mean age, 67 ± 13 years; 66% men) from a representative sample of 40 nephrology clinics in France. Exposures: Albuminuria, estimated glomerular filtration rate, CKD symptoms, lifestyle, comorbid conditions, and medications collected annually. Outcomes: Insomnia and EDS ≥ 3 times/week in the past 3 months assessed with a standardized questionnaire at baseline, 1-, 3-, and 5-year follow-ups Analytical Approach: Adjusted odds ratios of insomnia and EDS associated with time-updated exposures estimated with mixed effects logistic regressions. Results: Baseline prevalence of reported insomnia was 22% (95% confidence interval, 21%-24%) and that of EDS, 15% (14%-16%). Based on the 7,264 observations, neither prevalence was associated with albuminuria after adjustment for age and gender. The odds ratio of EDS alone increased significantly with decreasing estimated glomerular filtration rate, 1.16 (1.05-1.28 mL/min/1.73 m Limitations: Self-reported sleep disturbances and limited longitudinal inference. Conclusions: This study highlights the multifactorial nature of sleep disturbances in CKD and the potentially modifiable contribution of CKD symptoms and drug-induced effects.
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