Evidence map›Paper›PMID 42899179›Full record

ArticleBioactive materials2027

DNA-adsorbing nanozyme hydrogel reprograms the immuno-oxidative microenvironment to support stem cell-based cartilage repair in osteoarthritis.

Haoran Yu, Zhongyao Hu, Qiwei Tan, Chen Wang, Bo Wang, Yiqun Yan, Yangmang Yu, Fei Zhang, Mingjun Zhang, Yao Huang and 5 more

Abstract read
PubMed Full text at PMC Publisher
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Article in Bioactive materials, 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Haoran YuDepartment of Orthopedics, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China.
Zhongyao HuDepartment of Orthopedics, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China.
Qiwei TanDepartment of Spine Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China.
Chen WangDepartment of Orthopedics, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China.
Bo WangDepartment of Orthopedics, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China.
Yiqun YanDepartment of Orthopedics, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China.
Yangmang YuDepartment of Orthopedics, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China.
Fei ZhangDepartment of Orthopedics, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China.
Mingjun ZhangDepartment of Orthopedics, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China.
Yao HuangDepartment of Spine Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China.
Dechao CaiDepartment of Orthopedics, People's Hospital of Wuhe County, Bengbu, 233699, China.
Yue WangDepartment of Orthopedics, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China.
Hao ZhouDepartment of Spine Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China.
Duan WangOrthopaedic Research Institute, Department of Orthopaedics, West China Hospital, Sichuan University, Chengdu, 610041, China.
Wendan ChengDepartment of Orthopedics, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoarthritis (OA) is a prevalent degenerative joint disease, and stem cell therapy is often limited by a hostile joint microenvironment. Excessive reactive oxygen species (ROS) and damage-associated cell-free DNA (cfDNA) cooperatively drive innate immune activation, inflammatory macrophage polarization, and chondrogenic instability, forming an immuno-oxidative barrier to cartilage repair. Here, we developed a bioactive DNA-adsorbing nanozyme hydrogel (MNKB/HA) to remodel this niche and enhance BMSC-mediated cartilage repair. MNKB/HA integrates Mn

Indexed as

BMSCscfDNAImmuno-oxidative nicheNanozymesOsteoarthritisROS

Identifiers

PMID42899179
PMCPMC13679311

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.