Microenvironment-responsive injectable marine polysaccharide hydrogel empowered by bimetallic MOF nanozymes for in situ pancreatic cancer immunotherapy

Yihao Zhan, Chuanqin Shi, Jiqing Dong, Shihua Zhao, Xintao Gao, Junyao Li, Xiangyan Chen, Yantao Li

Abstract read

In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Yihao ZhanState Key Laboratory of Advanced Optical Polymer and Manufacturing Technology, Qingdao Key Laboratory of Biomacromolecular Drug Discovery and Development, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, 266042, China.

Chuanqin ShiCenter of Translational Medicine, Zibo Central Hospital Affiliated to Binzhou Medical University, Zibo, 255020, China.

Jiqing DongState Key Laboratory of Advanced Optical Polymer and Manufacturing Technology, Qingdao Key Laboratory of Biomacromolecular Drug Discovery and Development, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, 266042, China.

Shihua ZhaoCenter of Translational Medicine, Zibo Central Hospital Affiliated to Binzhou Medical University, Zibo, 255020, China.

Xintao GaoState Key Laboratory of Advanced Optical Polymer and Manufacturing Technology, Qingdao Key Laboratory of Biomacromolecular Drug Discovery and Development, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, 266042, China.

Junyao LiState Key Laboratory of Advanced Optical Polymer and Manufacturing Technology, Qingdao Key Laboratory of Biomacromolecular Drug Discovery and Development, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, 266042, China.

Xiangyan ChenState Key Laboratory of Advanced Optical Polymer and Manufacturing Technology, Qingdao Key Laboratory of Biomacromolecular Drug Discovery and Development, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, 266042, China.

Yantao LiState Key Laboratory of Advanced Optical Polymer and Manufacturing Technology, Qingdao Key Laboratory of Biomacromolecular Drug Discovery and Development, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, 266042, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatic cancer is characterized by a dense desmoplastic stroma and a profoundly immunosuppressive tumor microenvironment (TME), which jointly impede drug penetration and immune activation. Here, we report a microenvironment-responsive injectable marine polysaccharide hydrogel (G@ZnFe-Gel) empowered by a Zn/Fe bimetallic MOF nanozyme to achieve in situ pancreatic cancer immunotherapy

Indexed as

cGAS-STINGFerroptosisMOF nanozymesPancreatic cancerPolysaccharide hydrogels

Identifiers

PMID42899176

DOI10.1016/j.mtbio.2026.103735

PMCPMC13679371

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.