Evidence map›Paper›PMID 42899131›Full record

ArticleRSC pharmaceutics2026

Potential to modulate corneal epithelial repair

Margery E Purvis, Madelyn P Bucci, Tsian D Ramrattan, Shannon M Wallet, Mark H Schoenfisch

Abstract read
In one paragraph

Article in RSC pharmaceutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Margery E PurvisDepartment of Chemistry, University of North Carolina at Chapel Hill Chapel Hill NC 27599 USA schoenfisch@unc.edu.
Madelyn P BucciDepartment of Oral Biology, College of Dentistry, University of Florida Gainesville FL 32610 USA.
Tsian D RamrattanDepartment of Chemistry, University of North Carolina at Chapel Hill Chapel Hill NC 27599 USA schoenfisch@unc.edu.
Shannon M WalletDepartment of Oral Biology, College of Dentistry, University of Florida Gainesville FL 32610 USA.
Mark H SchoenfischDepartment of Chemistry, University of North Carolina at Chapel Hill Chapel Hill NC 27599 USA schoenfisch@unc.edu.ORCID https://orcid.org/0000-0002-2212-0658

Funding

Nitric oxide-releasing glycosaminoglycans for treating complex woundsR01DK132778 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Mark H Schoenfisch, Shannon Margaret Wallet · 2023 to 2026
$1.5M
NIDDK NIH HHS R01 DK132778
6 · The paper itself

Abstract

Bioactive wound therapies that protect injured tissue, promote regeneration, and prevent infection would represent a promising alternative to traditional passive treatments. In this study, nitric oxide (NO)-releasing glycosaminoglycans (GAGs) were synthesized and evaluated for their therapeutic potential in corneal wound healing. Low and high molecular weight hyaluronic acid (HA) and chondroitin sulfate (CS) derivatives of different sulfation patterns were synthesized and characterized with respect to NO release, antibacterial activity, cytotoxicity, and effects on human corneal epithelial cell proliferation and migration. A three-dimensional corneal tissue scratch closure model was subsequently used to assess

Identifiers

PMID42899131
PMCPMC13678718

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.