ArticleClinical kidney journal2026
Diffusion tensor MR neurography reveals altered sciatic and tibial nerve microstructure in chronic dialysis patients.
Article in Clinical kidney journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Uremic polyneuropathy is a complication of chronic kidney disease, presenting as a distal symmetric neuropathy mainly attributed to axonal damage. Electrophysiology provides limited insight into microstructural nerve alterations. Magnetic resonance neurography (MRN) may enable assessment of peripheral nerve integrity. This study aimed to quantify sciatic and tibial nerve microstructural changes in chronic dialysis patients and evaluate their clinical relevance. Methods: Thirty patients on chronic dialysis (DP)-without prediabetes or diabetes-and 30 healthy controls (HCs) underwent MRN, including diffusion tensor imaging (DTI). All MRN datasets of the distal thigh (30/30) were suitable for analysis. Four lower-leg examinations in the patient cohort (26/30) and three in the healthy group (27/30) were excluded because of motion artifacts. Fractional anisotropy (FA) was defined as the primary imaging outcome, while axial diffusivity (AD) and radial diffusivity (RD) were analyzed as secondary metrics. Electrophysiological testing was not available in four patients in the dialysis cohort (26/30). Results were compared between groups and correlated with electrophysiological, clinical, and laboratory findings. Results: FA of the sciatic (DP 0.44, HC 0.48, Discussion: The reduction in FA and AD, together with electrophysiological and clinical correlations, is compatible with a predominantly axonal pattern of peripheral nerve involvement in chronic dialysis patients. DTI detected peripheral nerve microstructural alterations associated with chronic dialysis. These findings support further longitudinal and disease control studies to determine the clinical utility of DTI as an imaging biomarker in chronic dialysis patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.