Evidence map›Paper›PMID 42899101›Full record

ArticleERJ open research2026

Alex G G Doruyter, Elizna Maasdorp, Marieke M van der Zalm, Andriëtte M Hiemstra, Megan Palmer, Stephanus T Malherbe, James A Seddon

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ERJ open research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alex G G DoruyterNuMeRI Node for Infection Imaging, Central Analytical Facilities, Stellenbosch University, Cape Town, South Africa.ORCID https://orcid.org/0000-0001-9294-1737
Elizna MaasdorpDivision of Immunology, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa.ORCID https://orcid.org/0000-0002-3402-169X
Marieke M van der ZalmDesmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.ORCID https://orcid.org/0000-0002-8787-9139
Andriëtte M HiemstraDivision of Immunology, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa.ORCID https://orcid.org/0000-0002-6331-9858
Megan PalmerDesmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.ORCID https://orcid.org/0000-0002-2534-2483
Stephanus T MalherbeDivision of Immunology, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa.ORCID https://orcid.org/0000-0002-7563-8231
James A SeddonDesmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.ORCID https://orcid.org/0000-0002-2296-2302

Funding

The long-term consequences of pulmonary tuberculosis and respiratory viruses on lung health in young South African childrenK43TW011028 · FIC · STELLENBOSCH UNIVERSITY · PI VAN DER ZALM, MARIEKE MARGREET · 2020 to 2024
$647k
FIC NIH HHS K43 TW011028
6 · The paper itself

Abstract

Background: Data on post-tuberculosis outcomes in adolescents are scarce. Although fluorine-18 fluorodeoxyglucose ( Methods: Early FDG PET/CT images of 50 adolescents (31 female, median age 17.2 years) with confirmed pulmonary tuberculosis were read visually and quantitative data of disease burden (total lung volume, cavity volume, total hard volume and total glycolytic activity (TGA)) were extracted and tested for associations with clinical risk factors and spirometry measures after treatment completion. Findings: Involvement of three or more lobes was present in 66% of adolescents, with consolidation in 84%, nodules in 92% and cavities in 84%. Comparatively, smokers had lower TGA values (p=0.034). Larger cavity volume was the strongest predictor of reduced forced expiratory volume in 1 s (FEV Interpretation: PET/CT features in this adolescent cohort matched patterns described in adults and were frequently severe. Radiological severity measures were associated with poorer spirometry after treatment. More data, including longitudinal imaging and functional outcomes, are required to better understand pathophysiology in this age group.

Identifiers

PMID42899101
PMCPMC13678914

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.