Evidence map›Paper›PMID 42899021›Full record

ReviewFrontiers in immunology2026

Inflammation identity crisis: pathogenic nature of platelet-derived transforming growth factor β in chronic inflammatory conditions.

Karli R Sutton, Rachel C Eisenhart, Meera V Singh

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Karli R SuttonDepartment of Immunology and Microbiology, University of Rochester School of Medicine and Dentistry, Rochester, NY, United States.
Rachel C EisenhartDepartment of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, NY, United States.
Meera V SinghDepartment of Immunology and Microbiology, University of Rochester School of Medicine and Dentistry, Rochester, NY, United States.

Funding

The T32 Predoctoral Training Program in Immunology (PTPI)T32AI007285 · NIAID · UNIVERSITY OF ROCHESTER · PI Scott Andrew Gerber, JACQUES Robert · 1986 to 2026
$7.6M
Role of platelet- monocyte interaction in promoting pro-atherogenic state in HIV-infected individualsR01HL160229 · NHLBI · UNIVERSITY OF ROCHESTER · PI Meera Vir Singh, Juilee Thakar · 2022 to 2026
$2.6M
Platelet-medicated deregulation of dendritic cell function- implications for anti-HIV immune responses and immunotherapyR21AI162076 · NIAID · UNIVERSITY OF ROCHESTER · PI SINGH, MEERA VIR · 2022 to 2023
$448k
NHLBI NIH HHS R01 HL160229NIAID NIH HHS R21 AI162076NIAID NIH HHS T32 AI007285
6 · The paper itself

Abstract

Chronic inflammatory conditions are associated with sustained platelet activation and subsequent release of platelet-derived immunomodulatory factors. Among these, platelets are the largest circulating reservoir of transforming growth factor β (TGFβ), and as such can be implicated in all physiological processes where TGFβ plays a crucial role. TGFβ is associated with immune regulation via dampening of Th

Indexed as

Blood PlateletsInflammationTransforming Growth Factor betaAnimalsChronic DiseaseHumansPlatelet ActivationTransforming Growth Factor betachronic inflammationfibrosisplateletsTGFβvascular disease

Identifiers

PMID42899021
PMCPMC13678468

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.