Evidence map›Paper›PMID 42898984›Full record

ArticleAdvanced functional materials2025

Engineered Peptides-based Hybrid-nested Microneedle Effectively Treat Biofilm-infected Diabetic Wounds.

Syed Muntazir Andrabi, Sm Shatil Shahriar, Yiran Tian, Farzad Hayati, Yajuan Su, Feng Zhang, Navatha S Sharma, Guangshun Wang, Shannon L Wong, Zheng Yan and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced functional materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Syed Muntazir AndrabiDepartment of Surgery-Transplant and Mary & Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Sm Shatil ShahriarDepartment of Surgery-Transplant and Mary & Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Yiran TianDepartment of Mechanical and Aerospace Engineering, University of Missouri, Columbia, MO 65211, USA.
Farzad HayatiDepartment of Internal Medicine Nephrology, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Yajuan SuDepartment of Surgery-Transplant and Mary & Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Feng ZhangDepartment of Chemical and Biomedical Engineering, University of Missouri, Columbia, MO, USA.
Navatha S SharmaDepartment of Surgery-Transplant and Mary & Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Guangshun WangDepartment of Pathology, Microbiology, and Immunology, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Shannon L WongDepartment of Surgery-Plastic Surgery, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Zheng YanDepartment of Chemical and Biomedical Engineering, University of Missouri, Columbia, MO, USA.
Guoliang HuangDepartment of Mechanical and Aerospace Engineering, University of Missouri, Columbia, MO 65211, USA.
Jingwei XieDepartment of Surgery-Transplant and Mary & Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA.

Funding

Novel Janus-type Antimicrobial Dressings for the Treatment of Biofilms in Chronic WoundsR01GM138552 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI WANG, GUANGSHUN, XIE, JINGWEI · 2020 to 2023
$2.2M
NIGMS NIH HHS R01 GM138552
6 · The paper itself

Abstract

Diabetic wounds with biofilm present a significant challenge in wound care, often leading to chronic inflammation, recurrent infections, impaired healing, and in severe cases, amputations. Addressing this critical challenge requires a multifaceted treatment strategy. Herein, we report a hybrid-nested microneedle scaffold (MQW-CMg-MOF) designed for efficient biofilm removal and accelerated healing of diabetic wounds. This scaffold integrates as a multifaceted system: the bottom layer features a nested microneedle patch embedded with vancomycin, the antimicrobial peptide W379, and the angiogenic QK peptide, while the top layer consists of chitosan cryogels incorporated with magnesium metal-organic frameworks. The nested microneedle patches are engineered to penetrate and mechanically disrupt biofilms and enable a programmed release of embedded agents, effectively addressing infection and promoting angiogenesis. Simultaneously, the cryogels serve as a substrate for scavenging reactive oxygen species and supporting cell ingrowth. The microneedle patches show substantial biofilm removal in vitro and in a preclinical diabetic swine biofilm-infected wound model compared to the control. Most importantly, the combined hybrid-nested microneedle arrays and cryogels effectively combat biofilm infection and promote wound healing in type 2 diabetic (db/db) mice. Overall, this multifunctional hybrid system shows promise in facilitating biofilm removal and enhancing the healing of diabetic wounds.

Indexed as

angiogenesisbiofilmcryogeldiabetic woundinflammationMicroneedlevancomycin

Identifiers

PMID42898984
PMCPMC13679834

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.