Evidence map›Paper›PMID 42898982›Full record

ArticleMedComm2026

Polyomavirus Drives Cerebellar Lesions in AIDS Monkeys With Ataxia.

Tian-Zhang Song, Li-Rong Zhang, Yun-Mei Wang, Yan Hu, Qing Li, Ren-Rong Tian, Liu-Meng Yang, Si-Dong Xiong, Dong-Dong Wu, Yong-Tang Zheng

Abstract read
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In one paragraph

Article in MedComm, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tian-Zhang Song *State Key Laboratory of Genetic Evolution & Animal Models National Resource Center For Non-Human Primates Kunming Institute of Zoology Chinese Academy of Sciences Kunming China.
Li-Rong Zhang *State Key Laboratory of Genetic Evolution & Animal Models National Resource Center For Non-Human Primates Kunming Institute of Zoology Chinese Academy of Sciences Kunming China.
Yun-Mei Wang *State Key Laboratory of Genetic Evolution & Animal Models National Resource Center For Non-Human Primates Kunming Institute of Zoology Chinese Academy of Sciences Kunming China.
Yan Hu *State Key Laboratory of Genetic Evolution & Animal Models National Resource Center For Non-Human Primates Kunming Institute of Zoology Chinese Academy of Sciences Kunming China.
Qing LiState Key Laboratory of Genetic Evolution & Animal Models National Resource Center For Non-Human Primates Kunming Institute of Zoology Chinese Academy of Sciences Kunming China.
Ren-Rong TianState Key Laboratory of Genetic Evolution & Animal Models National Resource Center For Non-Human Primates Kunming Institute of Zoology Chinese Academy of Sciences Kunming China.
Liu-Meng YangState Key Laboratory of Genetic Evolution & Animal Models National Resource Center For Non-Human Primates Kunming Institute of Zoology Chinese Academy of Sciences Kunming China.
Si-Dong XiongKIZ-SU Joint Laboratory of Animal Model and Drug Development College of Pharmaceutical Sciences Soochow University Suzhou China.
Dong-Dong WuState Key Laboratory of Genetic Evolution & Animal Models National Resource Center For Non-Human Primates Kunming Institute of Zoology Chinese Academy of Sciences Kunming China.
Yong-Tang ZhengState Key Laboratory of Genetic Evolution & Animal Models National Resource Center For Non-Human Primates Kunming Institute of Zoology Chinese Academy of Sciences Kunming China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cognitive and motor dysfunction occurs in 30%-50% of people with HIV/AIDS. Within this clinical spectrum, HIV-associated ataxia is an uncommon but debilitating disorder with poorly defined neuropathological mechanisms. This study investigated two rhesus macaques with chronic simian immunodeficiency virus (SIV) infection that developed progressive ataxia, characterized by postural imbalance and nystagmus. Comparative neuropathological profiling of cerebellar tissue from ataxic SIV-infected macaques, non-ataxic SIV-infected macaques, and uninfected controls revealed that ataxia was associated with diffuse cerebellar atrophy, disrupted tissue organization, Purkinje cell degeneration, demyelination, glial nodule formation, and prominent microglial neuroinflammation. Cerebellar infection with simian polyomavirus 40 (SV40), a member of the

Indexed as

AIDSataxianonhuman primate modelpolyomavirusSV40

Identifiers

PMID42898982
PMCPMC13679839

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.