ReviewPeerJ2026
Beyond the pump: a narrative review of the acute molecular, metabolic, and neuropsychological responses to a bout of resistance exercise.
Review in PeerJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Resistance training is widely recognized for its chronic adaptations, including strength, muscle hypertrophy, and improvements in musculoskeletal health. However, a single bout of resistance exercise also elicits a range of acute physiological and psychological responses across multiple systems. These immediate responses have generally been examined within individual physiological domains, with less attention given to their coexistence and temporal overlap following a single session. Methods: This narrative review synthesizes evidence relating to the acute systemic effects of a single bout of resistance exercise. Literature was identified through iterative searches of electronic databases and reference lists, with emphasis on primary human studies directly examining acute responses, alongside relevant systematic reviews, meta-analyses, and mechanistic literature. Results: Acute resistance exercise induces responses across endocrine and myokine, metabolic, vascular, pain-related, psychological, cognitive, and sleep-related domains. Contracting skeletal muscle releases myokines and other signalling molecules with potential systemic actions. Post-exercise energy expenditure and muscle protein synthesis may remain elevated during recovery, while glucose uptake and insulin sensitivity are enhanced. Acute resistance exercise can also produce exercise-induced hypoalgesia, reduce state anxiety, improve aspects of executive function and cognitive performance, and may influence sleep continuity and neurophysiological activity. These responses differ in their evidential basis and physiological significance, encompassing directly observed short-term effects, proposed regulatory mechanisms, and more tentative hypotheses regarding longer-term implications. Conclusion: A single bout of resistance exercise produces temporally overlapping responses across multiple physiological and psychological systems. These responses should not be assumed to represent adaptive remodelling or direct mechanisms of chronic health benefit. Nevertheless, integrating them provides a broader perspective on the immediate multisystem consequences of resistance exercise and may help inform future research examining how repeated acute responses relate to longer-term adaptation and health outcomes.
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Registered trials
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