Evidence map›Paper›PMID 42898914›Full record

ArticleRSC advances2026

Design, synthesis, and anticancer evaluation of Biginelli-derived DHPM-amide hybrids bearing clinically inspired kinase-directed pharmacophores: EGFR docking and DFT studies.

Sagar P Kothadiya, Jay B Maheta, Darshna K Lakhnotra, Yogesh O Bhola, Sureshkumar B Koradiya

Abstract read
In one paragraph

Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sagar P KothadiyaDepartment of Chemistry, Atamiya University Rajkot 360005 Gujarat India Suresh.koradiya@gmail.com.
Jay B MahetaDepartment of Chemistry, Shri M. P. Pandya Science College, Shri Govind Guru University Lunawada-389230 Godhra Gujarat India dryobhola@gmail.com.
Darshna K LakhnotraDepartment of Chemistry, Shri M. P. Pandya Science College, Shri Govind Guru University Lunawada-389230 Godhra Gujarat India dryobhola@gmail.com.
Yogesh O BholaDepartment of Chemistry, Shri M. P. Pandya Science College, Shri Govind Guru University Lunawada-389230 Godhra Gujarat India dryobhola@gmail.com.ORCID https://orcid.org/0000-0002-8882-5714
Sureshkumar B KoradiyaDepartment of Chemistry, Atamiya University Rajkot 360005 Gujarat India Suresh.koradiya@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of twelve novel dihydropyrimidine (DHPM)-amide hybrid conjugates (6a-c, 8a-c, 10a-c, and 12a-c) were rationally designed, synthesized, and biologically evaluated as potential EGFR-targeted anticancer agents against A549 non-small cell lung carcinoma (NSCLC) cells. The target compounds were constructed

Identifiers

PMID42898914
PMCPMC13678441

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.