ReviewCureus2026
Regenerative Medicine in the Management of Musculoskeletal Pain: Mechanisms, Clinical Applications, and Future Directions.
Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Musculoskeletal disorders represent a leading cause of global disability. Common causes of musculoskeletal pain include anomalies, repetitive strain, sports injuries, obesity, aging, inflammation, and degeneration. These conditions manifest as osteoarthritis, tendinopathy, low back pain, erosions, and fractures. Management of musculoskeletal pain uses multidisciplinary, multimodal approaches, including pharmacologic, non-pharmacologic, physical therapy, and surgical interventions. Conventional treatments such as simple analgesics, nonsteroidal anti-inflammatory drugs, corticosteroids, opioids in selected cases, and even surgery may provide symptomatic control at the expense of adverse effects such as gastrointestinal bleeding, addiction, dependence, and cartilage erosion. Regenerative medicine has emerged as a promising therapeutic approach for musculoskeletal pain encompassing modalities such as platelet-rich plasma (PRP), mesenchymal stem cells (MSCs) and their derivatives, gene therapy, and tissue-engineered scaffolds. These interventions may alleviate musculoskeletal pain through multiple biological mechanisms, including modulation of inflammation, desensitization of nociceptors, enhancement of tissue repair, and stimulation of cellular regeneration. A targeted literature search was conducted between 2011 and 2026 across major databases, including PubMed, MEDLINE, Web of Science, and Embase. The inclusion criteria focused on high-quality publications addressing the role of regenerative medicine modalities in musculoskeletal pain. The exclusion criteria included non-musculoskeletal pain, animal studies, and other publications such as editorials and case reports. This review shows promise and supports the potential role for regenerative therapies in the management of musculoskeletal conditions, but their effectiveness, safety, and feasibility vary substantially by modality, indication, product standardization, and study quality. The study identifies important knowledge gaps, limitations, and future directions in regenerative medicine, while also underscoring the need for better standardization and stronger comparative evidence.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.