Evidence map›Paper›PMID 42898690›Full record

ReviewFrontiers in oncology2026

Paraptosis, a new type of cell death that can be applied to cancer treatment.

Xudong Wang, Jiaxing Ma, Bowen Tan, Yang Wang, Zhengwan Wang, Chunlan Hou, Qingjuan Chen, Xiang Jin

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xudong Wang *Department of Orthopedics, Junlian County People's Hospital, Yibin, Sichuan, China.
Jiaxing Ma *West China School of Medicine, Sichuan University, Chengdu, China.
Bowen TanWest China School of Medicine, Sichuan University, Chengdu, China.
Yang WangDepartment of Breast Surgery, North Sichuan Medical College, Nanchong, Sichuan, China.
Zhengwan WangDepartment of Breast Surgery, North Sichuan Medical College, Nanchong, Sichuan, China.
Chunlan HouDepartment of Breast Surgery, North Sichuan Medical College, Nanchong, Sichuan, China.
Qingjuan ChenDepartment of Oncology, 3201 Hospital, Hanzhong, China.
Xiang JinDepartment of Breast Surgery, Yibin First People's Hospital, Yibin, Sichuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Paraptosis is a form of non-apoptotic cell death characterized by cytoplasmic vacuolization and swelling of the mitochondria and endoplasmic reticulum (ER). Recent studies have demonstrated that inducing paraptosis in cancer cells can circumvent apoptosis resistance and synergize with other forms of cell death and tumor immunity, providing a novel strategy for anti-tumor therapy. The underlying mechanism of paraptosis involves ER stress triggered by inducers, leading to the swelling of the ER and mitochondria. This subsequently alters the cytoskeleton and disrupts molecular processes, such as calcium (Ca

Indexed as

cancer therapycell deathendoplasmic reticulummolecular mechanismsparaptosis

Identifiers

PMID42898690
PMCPMC13678465

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.