Evidence map›Paper›PMID 42898688›Full record

ReviewFrontiers in bioengineering and biotechnology2026

Advances and applications of engineered protein therapeutics and their role in precision medicine.

Wadha Aldossary, Nada Alqahtani, Layla Asiri, Noora Alkhurayef, Samar Alagl, Sana Alturki, Duha Saad, Mashael Al Yahya, Samah Al-Harthi

Abstract readReview
In one paragraph

Review in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wadha AldossarySaudi Food and Drug Authority, Riyadh, Saudi Arabia.
Nada AlqahtaniSaudi Food and Drug Authority, Riyadh, Saudi Arabia.
Layla AsiriSaudi Food and Drug Authority, Riyadh, Saudi Arabia.
Noora AlkhurayefSaudi Food and Drug Authority, Riyadh, Saudi Arabia.
Samar AlaglSaudi Food and Drug Authority, Riyadh, Saudi Arabia.
Sana AlturkiSaudi Food and Drug Authority, Riyadh, Saudi Arabia.
Duha SaadSaudi Food and Drug Authority, Riyadh, Saudi Arabia.
Mashael Al YahyaSaudi Food and Drug Authority, Riyadh, Saudi Arabia.
Samah Al-HarthiSaudi Food and Drug Authority, Riyadh, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Proteins are a vital class of biomolecules. They play essential roles in biological processes, including building cellular structures, forming cellular channels and receptors, catalyzing biological reactions, transporting molecules, and contributing to immune defense mechanisms. Advances in protein engineering have enabled the genetic modification of naturally occurring proteins, using recombinant deoxyribonucleic acid (DNA) technology, leading to the development of therapeutic proteins with enhanced specificity, stability, and clinical performance. Despite the rapid growth of engineered biologics, a comprehensive understanding of how these innovations intersect with precision medicine remains limited. This review addresses this gap by summarizing the major contemporary approaches used in therapeutic protein engineering, including directed evolution, rational design, and

Indexed as

biologicsdirected evolutionengineered protein therapeuticsmonoclonal antibodiesprecision medicineprotein engineeringrecombinant DNA technology

Identifiers

PMID42898688
PMCPMC13678489

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.