Evidence map›Paper›PMID 42898649›Full record

ArticleBioactive materials2027

Cationized gelatin nanosphere-mediated release-controlled RNA interference targeting mTORC1 protects against intervertebral disc degeneration.

Yoshiaki Hiranaka, Takashi Yurube, Naotoshi Kumagai, Yoshiki Takeoka, Yutaro Kanda, Kohei Kuroshima, Masahiko Furuya, Daisuke Nakagawa, Takahiro Kitano, Akihiro Miyajima and 4 more

Abstract read
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In one paragraph

Article in Bioactive materials, 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yoshiaki HiranakaDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Takashi YurubeDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Naotoshi KumagaiDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Yoshiki TakeokaDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Yutaro KandaDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Kohei KuroshimaDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Masahiko FuruyaDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Daisuke NakagawaDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Takahiro KitanoDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Akihiro MiyajimaDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Taichi WashisakaDepartment of Regeneration Science and Engineering, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.
Kenichiro KakutaniDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Ryosuke KurodaDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Yasuhiko TabataDepartment of Plastic and Reconstructive Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intervertebral disc degeneration is a major cause of chronic low back pain, but effective disease-modifying therapies remain unavailable. Sustained and localized RNA interference (RNAi) offers a promising therapeutic approach; however, its application to the disc is limited by poor local retention and delivery-related toxicity. Here, we developed a release-controlled RNAi platform using biodegradable cationized gelatin nanospheres (cGNS) to deliver small interfering RNA (siRNA) targeting

Indexed as

Cationized gelatin nanospheresControlled releaseIntervertebral disc degenerationPI3K–AKT–mTOR signalingRNA interferencesiRNA delivery

Identifiers

PMID42898649
PMCPMC13678022

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.