Evidence map›Paper›PMID 42898639›Full record

ArticleBioactive materials2027

Cytotoxic T lymphocyte-inspired nanotherapeutics chaperoning granzyme B for tumor immune remodeling.

Yujie Chen, Yongxin Zhang, Jiajing Chen, Xiaolei Du, Shuyu Wang, Zixuan Ma, Hongji Zhou, Jinpu Yu, Feihe Ma, Linqi Shi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yujie ChenKey Laboratory of Functional Polymer Materials of Ministry of Education, Institute of Polymer Chemistry, State Key Laboratory of Medicinal Chemical Biology, Frontiers Science Center for New Organic Matter, Haihe Laboratory of Sustainable Chemical Transformations, College of Chemistry, Nankai University, Tianjin, 300071, China.
Yongxin ZhangKey Laboratory of Functional Polymer Materials of Ministry of Education, Institute of Polymer Chemistry, State Key Laboratory of Medicinal Chemical Biology, Frontiers Science Center for New Organic Matter, Haihe Laboratory of Sustainable Chemical Transformations, College of Chemistry, Nankai University, Tianjin, 300071, China.
Jiajing ChenKey Laboratory of Functional Polymer Materials of Ministry of Education, Institute of Polymer Chemistry, State Key Laboratory of Medicinal Chemical Biology, Frontiers Science Center for New Organic Matter, Haihe Laboratory of Sustainable Chemical Transformations, College of Chemistry, Nankai University, Tianjin, 300071, China.
Xiaolei DuKey Laboratory of Functional Polymer Materials of Ministry of Education, Institute of Polymer Chemistry, State Key Laboratory of Medicinal Chemical Biology, Frontiers Science Center for New Organic Matter, Haihe Laboratory of Sustainable Chemical Transformations, College of Chemistry, Nankai University, Tianjin, 300071, China.
Shuyu WangCancer Molecular Diagnostics Core, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Clinical Research Center for Cancer, Tianjin, 300060, China.
Zixuan MaKey Laboratory of Functional Polymer Materials of Ministry of Education, Institute of Polymer Chemistry, State Key Laboratory of Medicinal Chemical Biology, Frontiers Science Center for New Organic Matter, Haihe Laboratory of Sustainable Chemical Transformations, College of Chemistry, Nankai University, Tianjin, 300071, China.
Hongji ZhouKey Laboratory of Functional Polymer Materials of Ministry of Education, Institute of Polymer Chemistry, State Key Laboratory of Medicinal Chemical Biology, Frontiers Science Center for New Organic Matter, Haihe Laboratory of Sustainable Chemical Transformations, College of Chemistry, Nankai University, Tianjin, 300071, China.
Jinpu YuCancer Molecular Diagnostics Core, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Clinical Research Center for Cancer, Tianjin, 300060, China.
Feihe MaKey Laboratory of Functional Polymer Materials of Ministry of Education, Institute of Polymer Chemistry, State Key Laboratory of Medicinal Chemical Biology, Frontiers Science Center for New Organic Matter, Haihe Laboratory of Sustainable Chemical Transformations, College of Chemistry, Nankai University, Tianjin, 300071, China.
Linqi ShiCancer Molecular Diagnostics Core, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Clinical Research Center for Cancer, Tianjin, 300060, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

T cell-based cancer immunotherapies have transformed oncology; however, their clinical benefit remains limited in immunologically cold tumors, where poor T cell infiltration and impaired effector function weaken endogenous tumor cell killing. Here, we developed GrB@A-nChap, a cytotoxic T lymphocyte (CTL)-inspired nanotherapeutic that chaperones granzyme B (GrB) into the tumor cell cytosol to supplement deficient cytotoxic effector activity in "cold" tumors. Mechanistically, GrB@A-nChap protects GrB under physiological conditions, undergoes partial protonation in the mildly acidic tumor microenvironment to enhance tumor cell uptake, and further responds to lysosomal acidity to promote acidity-dependent lysosomal escape and cytosolic GrB release. Cytosolic GrB then induces mitochondrial dysfunction, caspase-3 activation, and GSDME cleavage, thereby triggering an apoptosis-pyroptosis cascade. This cell death process is accompanied by ICD-associated molecular signals and enhanced dendritic cell maturation.

Indexed as

Apoptosis-pyroptosisCancer immunotherapyCytosolic protein deliveryGranzyme BNanochaperone

Identifiers

PMID42898639
PMCPMC13677969

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.