ArticleCurrent research in toxicology2026
Investigation of inflammatory mechanisms induced by mechlorethamine in mouse ear.
Article in Current research in toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Mechlorethamine (HN2) is toxic to the skin and causes inflammation accompanied by disruption of the dermal-epidermal junction (DEJ), commonly known as vesication. HN2 is a sulfur mustard mimic used in research settings to investigate the pharmaco-toxic effects of vesicants. Effective medical countermeasures for vesicant-induced injury remain limited, underscoring the need to identify novel targets for reducing vesication. The present study used HN2 dissolved in dimethyl sulfoxide (DMSO) to induce mouse ear edema and investigate the contribution of the complement system (CS) to skin responses 24 h after exposure to HN2, with DMSO serving as the vehicle control. Tissues were homogenized and processed for proteomic analysis to examine the protein milieu in skin actively responding to HN2-mediated cutaneous injury. Comparative analysis identified 695 proteins that were differentially expressed between the vehicle- and HN2-treated groups (
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