SynthesisFrontiers in medicine2026
Global research trends and emerging themes of ketamine in perioperative neurocognitive disorders: a bibliometric analysis.
Synthesis in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Within the contemporary perioperative neurocognitive disorder (PND) framework, postoperative neurocognitive outcomes include postoperative delirium, delayed neurocognitive recovery, and postoperative neurocognitive disorder. Interest in ketamine and its enantiomers has increased, but the clinical literature on perioperative neurocognitive outcomes remains heterogeneous. This study mapped the global research landscape, collaboration structure, thematic evolution, and recently intensified research themes at the intersection of ketamine and PNDs. Methods: Publications indexed in the Web of Science Core Collection (WoSCC) and Scopus were retrieved using a prespecified search strategy. English-language articles and reviews published from 2006 to 2025 were included. Records were integrated and deduplicated using a Python-based bibliographic consolidation workflow. VOSviewer 1.6.20 was used for collaboration, citation, and author-keyword analyses, whereas CiteSpace 6.4.R2 Advanced was used for keyword burst detection. A WoSCC-only sensitivity analysis assessed robustness to database composition. Results: After database restrictions, 559 records remained (WoSCC, Conclusions: Research on ketamine and perioperative neurocognitive outcomes has expanded rapidly, particularly since 2020. Recent literature increasingly emphasizes esketamine, contemporary neurocognitive terminology, mechanistic questions, and delayed neurocognitive recovery. These bibliometric patterns represent research attention rather than evidence of clinical efficacy. Future studies should distinguish ketamine formulations and enantiomers, use standardized PND definitions and outcome windows, and prioritize adequately powered multicenter designs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.