ArticleFrontiers in bioengineering and biotechnology2026
Upcycling agricultural residues into polyhydroxyalkanoates through pilot-scale mixed microbial culture processes.
Article in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
Polyhydroxyalkanoates (PHAs) produced by mixed microbial cultures (MMCs) represent a promising alternative to conventional plastics, enabling the valorisation of agricultural residues within circular biorefineries. However, despite extensive laboratory-scale research, integrated pilot-scale studies encompassing the complete production chain, from feedstock fermentation to downstream polymer recovery, remain scarce. In this study, poly (hydroxybutyrate-hydroxyvalerate) (PHBV) production from agricultural residues was investigated in a pilot plant integrated within a full-scale agricultural anaerobic digestion facility. The process included acidogenic fermentation, microbial selection, PHBV accumulation, biomass recovery, while downstream extraction and purification were evaluated at laboratory scale on pilot-produced biomass. A total of 15 pilot-scale campaigns were carried out, allowing progressive optimisation. Two representative campaigns were selected: Batch 12, fed with a synthetic carboxylic acid (CA) mixture, and Batch 14, which used a real agricultural feedstock derived from cattle slurry and maize silage. Acidogenic fermentation of the agricultural substrate produced up to 16.7 gCOD/L of CAs, with valeric acid accumulation, providing suitable precursors for PHBV synthesis. Microbial community analysis confirmed the successful enrichment of recognised PHA-storing genera, including
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