ArticleFrontiers in plant science2026
Light spectrum effects on huperzine A and B accumulation in axenic gametophyte cultures of
Article in Frontiers in plant science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Huperzine A (HupA) and huperzine B (HupB) are high-value Lycopodiaceae alkaloids with potent, reversible acetylcholinesterase (AChE) inhibitory activity and NMDA receptor antagonism. Their supply is limited by impractical field cultivation and conservation constraints on wild harvesting. Here, we evaluated axenic gametophyte cultures of Methods: Cultures were maintained for 24 weeks under three light treatments (WHITE-L, BLUE-L and RED-BLUE-L) or darkness. HupA and HupB were quantified by HPLC-DAD, while LC-MS/IT-TOF and MS/MS-supported profiling were used for target-alkaloid confirmation and characterization of the multi-component extract composition. Extracts standardized to HupA equivalents were evaluated for AChE inhibition. Results: LED spectral control shaped HupA/HupB accumulation patterns. BLUE-L (≈450 nm) was associated with the strongest increase in HupA content, reaching 4.83 ± 0.21 mg·g Discussion: The weak-to-moderate relationship between HupA content and AChE inhibition suggests that optimization of
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