ArticleFrontiers in pharmacology2026
Oliceridine and morphine differentially modulate the gut microbiota-intestinal barrier axis in a rat postoperative pain model.
Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Oliceridine is a novel G protein-biased μ-opioid receptor agonist with potentially improved gastrointestinal tolerability compared with conventional opioids. However, its impact on postoperative intestinal homeostasis-specifically the gut microbiota and intestinal barrier-remains poorly understood. Methods: A postoperative pain model was established in male Sprague-Dawley rats using the Brennan plantar incision method. Animals were randomly assigned to four groups: non-incision control (CON), plantar incision plus normal saline, plantar incision plus oliceridine (OLI, 1 mg/kg subcutaneous bolus followed by continuous infusion at 1 mg/kg/day for 72 h), and plantar incision plus morphine (MF, 5 mg/kg subcutaneous bolus followed by continuous infusion at 5 mg/kg/day for 72 h). Analgesic efficacy was assessed by mechanical withdrawal threshold (MWT) and area under the curve (AUC). Intestinal morphology, epithelial Claudin-1 expression by immunofluorescence (n = 4 per group), gut microbiota composition (16S rRNA gene sequencing, n = 6 per group), and host ileal transcriptomic profiles (RNA-seq, n = 3 per group) were evaluated. Results: Oliceridine and morphine produced comparable analgesia, as reflected by MWT AUC (P < 0.0001 vs. NS; OLI vs. MF: P = 0.8770). Both opioids alleviated postoperative mechanical hypersensitivity. Compared with NS, opioid treatment increased the relative abundance of Conclusion: Oliceridine and morphine produced comparable analgesia. Exploratory microbiome analysis identified a potential
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