ReviewBioactive materials2027
Advanced cell-instructive bio-inks: Engineering multiscale niches for functional tissue formation.
Review in Bioactive materials, 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Three-dimensional bioprinting has transformed tissue fabrication by enabling the precise spatial organization of living cells and biomaterials into biomimetic tissue constructs. However, advances in manufacturing have outpaced the development of bio-inks capable of actively directing tissue formation. Most existing bio-inks remain optimized for printability, rheological behaviour, and structural fidelity, while providing limited control over the biological processes that govern tissue morphogenesis, functional maturation, and regeneration. This review examines the emerging paradigm of cell-instructive bio-inks, which integrate biological regulation directly into material design to recreate the cellular microenvironments that guide tissue development. We present a unifying framework that classifies these bio-inks according to three complementary regulatory dimensions: biochemical niches that regulate cell fate through molecular signalling and regenerative matrices; architectural niches that direct tissue organization through spatial and structural cues; and metabolic niches that modulate oxygen availability, redox homeostasis, and cellular metabolism. We further discuss strategies for integrating these instructive functions within multifunctional bio-inks, together with scalable manufacturing, and artificial intelligence-assisted bio-ink design. By redefining bio-inks as active regulators of cellular behaviour, this review establishes a conceptual framework for engineering next-generation bio-inks capable of orchestrating tissue development, functional maturation, and regenerative outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.