Evidence map›Paper›PMID 42898439›Full record

ArticleMaterials today. Bio2026

Hyaluronic acid-based osmolality-responsive immediate-release microneedles co-loading baicalein and astaxanthin for oral ulcer therapy.

Jinfan Yang, Kaihong Shi, Jiachen Wang, Huimin Liu, Yang Zhang, Xiaoyu Guang, Siyuan Wang, Wenxi Lei, Yuxiao Wang, Mingqian Tan and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jinfan YangComprehensive Breast Center, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.
Kaihong ShiComprehensive Breast Center, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.
Jiachen WangNational Demonstration Center for Experimental Light Chemistry Engineering Education, Shaanxi Provincial Key Laboratory of Papermaking Technology and Specialty Paper Development, College of Bioresources Chemical and Materials Engineering, Shaanxi University of Science & Technology, Xi'an, 710021, China.
Huimin LiuNational Demonstration Center for Experimental Light Chemistry Engineering Education, Shaanxi Provincial Key Laboratory of Papermaking Technology and Specialty Paper Development, College of Bioresources Chemical and Materials Engineering, Shaanxi University of Science & Technology, Xi'an, 710021, China.
Yang ZhangSchool of Basic Medical Sciences, Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education, Xi'an Jiaotong University, Xi'an, 710061, China.
Xiaoyu GuangSchool of Basic Medical Sciences, Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education, Xi'an Jiaotong University, Xi'an, 710061, China.
Siyuan WangComprehensive Breast Center, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.
Wenxi LeiComprehensive Breast Center, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.
Yuxiao WangAcademy of Food Interdisciplinary Science, School of Food Science and Technology, Dalian Polytechnic University, Qinggongyuan1, Ganjingzi District, Dalian, 116034, China.
Mingqian TanAcademy of Food Interdisciplinary Science, School of Food Science and Technology, Dalian Polytechnic University, Qinggongyuan1, Ganjingzi District, Dalian, 116034, China.
Xiaobin MaComprehensive Breast Center, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.
Hao WuComprehensive Breast Center, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral ulcers, a prevalent mucosal disorder, are clinically managed by topical corticosteroids and immunosuppressants to alleviate symptoms. However, conventional therapies suffer from suboptimal drug bioavailability, inconsistent efficacy, and potential adverse effects. To address these limitations, using natural carbohydrate polymer hyaluronic acid (HA) with excellent biocompatibility, as the main substrate, we constructed the osmolality-responsive immediate-release microneedles (MNs) platform (GA@BA&Ast MNs) co-loading baicalein (BA) and astaxanthin (Ast) for oral ulcer therapy, which effectively addresses traditional treatment bottlenecks via responsive immediate-release and efficient absorption. The platform's core innovation lies in its dynamically controllable release mechanism, which is triggered specifically by the oral microenvironment. Its osmolality-responsive mechanism, relying on HA-Ca

Indexed as

AstaxanthinBaicaleinHyaluronic acidImmediate releaseOral ulcersResponsive microneedles

Identifiers

PMID42898439
PMCPMC13677995

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.