Evidence map›Paper›PMID 42898399›Full record

ArticleBioactive materials2027

Theranostic peptide-selenium hydrogel targeting NETs-mitochondrial dysfunction-pyroptosis axis for chronic diabetic wound repair.

Xin Dan, Han Chen, Songjie Li, Pu Yang, Yikun Ju, Xiangjun Liu, Tong Li, Lanjie Lei, Yang Li, Xing Fan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Xin DanDepartment of Plastic and Reconstructive Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
Han ChenDepartment of Plastic and Reconstructive Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
Songjie LiDepartment of Plastic and Reconstructive Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
Pu YangDepartment of Plastic and Reconstructive Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
Yikun JuDepartment of Plastic and Aesthetic (Burn) Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Xiangjun LiuDepartment of Plastic and Reconstructive Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
Tong LiDepartment of Plastic and Reconstructive Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
Lanjie LeiKey Laboratory of Artificial Organs and Computational Medicine of Zhejiang Province, Shulan International Medical College, Institute of Translational Medicine, Zhejiang Shuren University, Hangzhou, 310015, China.
Yang LiDepartment of Plastic and Reconstructive Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
Xing FanDepartment of Plastic and Reconstructive Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic diabetic wounds are characterized by persistent inflammation, elevated oxidative stress, and impaired angiogenesis. However, effective strategies that simultaneously elucidate the underlying mechanisms and enable precise interventions remain scarce. This study aims to identify the neutrophil extracellular traps (NETs)-mitochondrial dysfunction-pyroptosis pathway as a key driver of impaired angiogenesis in diabetic wounds and to construct an intelligent composite hydrogel with pH-responsiveness and monitoring functions. The system utilizes a pH-responsive oxidized astragalus polysaccharide-gelatin hydrogel matrix that loads and enables the on-demand release of composite particles containing selenium and the antimicrobial peptide Andersonin-W1. These particles inhibit NETs formation, improve mitochondrial function, and reduce pyroptosis. Additionally, the system incorporates pH-responsive fluorescent carbon dots for visual monitoring of the wound microenvironment.

Indexed as

Diabetic woundsMitochondrial dysfunctionNeutrophil extracellular trapsPyroptosisTheranostic

Identifiers

PMID42898399
PMCPMC13677966

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.